^
Association details:
| Biomarker: | PIK3CA E545K |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | pictilisib (GDC-0941) (PI3K inhibitor) |
| Direction: | Resistant |
Evidence:
Title:
Response of Head and Neck Squamous Cell Carcinoma Cells Carrying PIK3CA Mutations to Select Targeted Therapies
Excerpt:
...treatment with GDC-0941 also revealed a relative resistance in PI3K-mutant carrying cells.
DOI:
10.1001/jamaoto.2015.0471
