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Association details:
Biomarker:PIK3CA E545K
Cancer:Breast Cancer
Drug:pictilisib (GDC-0941) (PI3K inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system

Excerpt:
PIK3CA, but not AKT1 mutation, increased sensitivity to the PI3K inhibitor GDC-0941 and the allosteric AKT inhibitor MK-2206.
DOI:
10.1158/1078-0432.CCR-13-0884