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BIOMARKER:
PIK3CA amplification
i
Other names:
PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
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Entrez ID:
5290
Related biomarkers:
Expression
Mutation
Others
‹
PIK3CA expression (3)
PIK3CA overexpression (1)
PIK3CA expression (3)
PIK3CA overexpression (1)
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Associations
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Trials
VERI cancer hierarchy
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PIK3CA amplification
HER2 Positive Breast Cancer
PIK3CA amplification
HER2 Positive Breast Cancer
PF-05212384 + trastuzumab-pkrb
Sensitive: C3 – Early Trials
PF-05212384 + trastuzumab-pkrb
Sensitive
:
C3
PF-05212384 + trastuzumab-pkrb
Sensitive: C3 – Early Trials
PF-05212384 + trastuzumab-pkrb
Sensitive
:
C3
PIK3CA amplification
Chordoma
PIK3CA amplification
Chordoma
everolimus
Sensitive: C3 – Early Trials
everolimus
Sensitive
:
C3
everolimus
Sensitive: C3 – Early Trials
everolimus
Sensitive
:
C3
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
alpelisib + tipifarnib
Sensitive: C3 – Early Trials
alpelisib + tipifarnib
Sensitive
:
C3
alpelisib + tipifarnib
Sensitive: C3 – Early Trials
alpelisib + tipifarnib
Sensitive
:
C3
PIK3CA amplification
Prostate Cancer
PIK3CA amplification
Prostate Cancer
nivolumab
Resistant: C3 – Early Trials
nivolumab
Resistant
:
C3
nivolumab
Resistant: C3 – Early Trials
nivolumab
Resistant
:
C3
PIK3CA amplification
Non Small Cell Lung Cancer
PIK3CA amplification
Non Small Cell Lung Cancer
GDC-0941
Sensitive: D – Preclinical
GDC-0941
Sensitive
:
D
GDC-0941
Sensitive: D – Preclinical
GDC-0941
Sensitive
:
D
PIK3CA amplification
Gastric Cancer
PIK3CA amplification
Gastric Cancer
alpelisib
Sensitive: D – Preclinical
alpelisib
Sensitive
:
D
alpelisib
Sensitive: D – Preclinical
alpelisib
Sensitive
:
D
PIK3CA amplification
HER2 Positive Breast Cancer
PIK3CA amplification
HER2 Positive Breast Cancer
LX-086
Sensitive: D – Preclinical
LX-086
Sensitive
:
D
LX-086
Sensitive: D – Preclinical
LX-086
Sensitive
:
D
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
tipifarnib
Sensitive: D – Preclinical
tipifarnib
Sensitive
:
D
tipifarnib
Sensitive: D – Preclinical
tipifarnib
Sensitive
:
D
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
GDC-0032
Sensitive: D – Preclinical
GDC-0032
Sensitive
:
D
GDC-0032
Sensitive: D – Preclinical
GDC-0032
Sensitive
:
D
PIK3CA amplification
Lung Cancer
PIK3CA amplification
Lung Cancer
PI3K inhibitor + EZH2 inhibitor
Sensitive: D – Preclinical
PI3K inhibitor + EZH2 inhibitor
Sensitive
:
D
PI3K inhibitor + EZH2 inhibitor
Sensitive: D – Preclinical
PI3K inhibitor + EZH2 inhibitor
Sensitive
:
D
PIK3CA amplification
Lung Cancer
PIK3CA amplification
Lung Cancer
EZH2 inhibitor
Sensitive: D – Preclinical
EZH2 inhibitor
Sensitive
:
D
EZH2 inhibitor
Sensitive: D – Preclinical
EZH2 inhibitor
Sensitive
:
D
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
PIK3CA amplification
Squamous Cell Carcinoma of Head and Neck
palbociclib + alpelisib
Sensitive: D – Preclinical
palbociclib + alpelisib
Sensitive
:
D
palbociclib + alpelisib
Sensitive: D – Preclinical
palbociclib + alpelisib
Sensitive
:
D
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