^
Association details:
| Biomarker: | PIK3CA amplification |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | pictilisib (GDC-0941) (PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
Excerpt:
Cell lines harboring pathway alterations (receptor tyrosine kinase activation, PI3K mutation or amplification, and PTEN loss) were exquisitely sensitive to the PI3K inhibitor GDC 0941....
DOI:
10.1158/1078-0432.CCR-12-2347
