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Association details:
| Biomarker: | PGBD5 overexpression |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | ceralasertib (AZD6738) (ATR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors
Excerpt:
...for PDX2 neuroblastoma tumor, which had relatively high PGBD5 expression (Fig. 7B), we observed significant reduction in tumor growth upon single-agent AZD6738 and cisplatin treatment, as compared to vehicle control (P = 0.032 and 0.079, respectively; Fig. 7D).
DOI:
10.1126/scitranslmed.aam9078
