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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Identification of Wee1 as target in combination with avapritinib for Gastrointestinal Stromal Tumor treatment

Published date:
12/15/2020
Excerpt:
In vitro and in vivo studies revealed significant efficacy of MK-1775 (Wee1 inhibitor) in combination with avapritinib in KIT and PDGFRA-mutant GIST cell lines, and notable efficacy of MK-1775 as a monotherapy in the PDGFRA-mutant line. 
DOI:
10.1172/jci.insight.143474