CANCER:

Gastrointestinal Stromal Tumor

KIT positive KIT positive	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: A1 - Approval
PDGFRA D842V PDGFRA D842V	Gastrointestinal Stromal Tumor GIST	avapritinib Sensitive: A1 - Approval
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	sunitinib Sensitive: A1 - Approval
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	ripretinib Sensitive: A1 - Approval
PDGFRA exon 18 mutation PDGFRA exon 18 mutation	Gastrointestinal Stromal Tumor GIST	avapritinib Sensitive: A1 - Approval
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	regorafenib Sensitive: A1 - Approval
KIT expression KIT expression	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: A1 - Approval
NTRK2 fusion NTRK2 fusion	Gastrointestinal Stromal Tumor GIST	entrectinib Sensitive: A2 - Guideline
NTRK1 fusion NTRK1 fusion	Gastrointestinal Stromal Tumor GIST	entrectinib Sensitive: A2 - Guideline
NTRK3 fusion NTRK3 fusion	Gastrointestinal Stromal Tumor GIST	entrectinib Sensitive: A2 - Guideline
NTRK3 fusion NTRK3 fusion	Gastrointestinal Stromal Tumor GIST	larotrectinib Sensitive: A2 - Guideline
NTRK2 fusion NTRK2 fusion	Gastrointestinal Stromal Tumor GIST	larotrectinib Sensitive: A2 - Guideline
NTRK1 fusion NTRK1 fusion	Gastrointestinal Stromal Tumor GIST	larotrectinib Sensitive: A2 - Guideline
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	cabozantinib tablet Sensitive: A2 - Guideline
PDGFRA exon 18 mutation PDGFRA exon 18 mutation	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: A2 - Guideline
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: A2 - Guideline
PDGFRA D842V PDGFRA D842V	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: A2 - Guideline
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	sorafenib Sensitive: A2 - Guideline
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	pazopanib Sensitive: A2 - Guideline
No biomarker No biomarker	Gastrointestinal Stromal Tumor GIST	nilotinib Sensitive: A2 - Guideline
KIT mutation KIT mutation	Gastrointestinal Stromal Tumor GIST	ripretinib Sensitive: B - Late Trials
PDGFRA mutation PDGFRA mutation	Gastrointestinal Stromal Tumor GIST	ripretinib Sensitive: B - Late Trials
KIT mutation KIT mutation	Gastrointestinal Stromal Tumor GIST	TAS-116 Sensitive: B - Late Trials
PDGFRA mutation PDGFRA mutation	Gastrointestinal Stromal Tumor GIST	avapritinib Sensitive: C2 – Inclusion Criteria
KIT mutation KIT mutation	Gastrointestinal Stromal Tumor GIST	avapritinib Sensitive: C2 – Inclusion Criteria
PDGFRA mutation PDGFRA mutation	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C2 – Inclusion Criteria
KIT exon 11 mutation KIT exon 11 mutation	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C2 – Inclusion Criteria
KIT mutation KIT mutation	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C2 – Inclusion Criteria
KIT exon 11 mutation KIT exon 11 mutation	Gastrointestinal Stromal Tumor GIST	ponatinib Sensitive: C2 – Inclusion Criteria
PDGFRA D842V PDGFRA D842V	Gastrointestinal Stromal Tumor GIST	ARO-002 Sensitive: C2 – Inclusion Criteria
KIT mutation KIT mutation	Gastrointestinal Stromal Tumor GIST	sunitinib + PLX9486 Sensitive: C3 – Early Trials
KIT exon 11 mutation + KIT exon 17 mutation KIT exon 11 mutation + KIT exon 17 mutation	Gastrointestinal Stromal Tumor GIST	nilotinib Sensitive: C3 – Early Trials
KIT exon 9 mutation KIT exon 9 mutation	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: C3 – Early Trials
TEKT4 mutation TEKT4 mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Resistant: C3 – Early Trials
SUFU mutation SUFU mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Resistant: C3 – Early Trials
SDHC mutation SDHC mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
TMEM127 mutation TMEM127 mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
SRC mutation SRC mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
TP53 mutation TP53 mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
APC mutation APC mutation	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
KIT N822K KIT N822K	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
KIT N820Y KIT N820Y	Gastrointestinal Stromal Tumor GIST	dasatinib Sensitive: C3 – Early Trials
KIT V560E KIT V560E	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
KIT V559_E561del KIT V559_E561del	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
KIT M552_V555delMYEV KIT M552_V555delMYEV	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
PDGFRA I843_D846delIMHD PDGFRA I843_D846delIMHD	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
KIT W557_V559>F KIT W557_V559>F	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
KIT W557_V559>C KIT W557_V559>C	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
KIT exon 9 mutation KIT exon 9 mutation	Gastrointestinal Stromal Tumor GIST	regorafenib Sensitive: C3 – Early Trials
KIT exon 9 mutation KIT exon 9 mutation	Gastrointestinal Stromal Tumor GIST	sunitinib Sensitive: C3 – Early Trials
PDGFRA D842V PDGFRA D842V	Gastrointestinal Stromal Tumor GIST	sunitinib Resistant: C3 – Early Trials
KIT exon 11 mutation KIT exon 11 mutation	Gastrointestinal Stromal Tumor GIST	nilotinib Sensitive: C3 – Early Trials
KIT exon 9 mutation KIT exon 9 mutation	Gastrointestinal Stromal Tumor GIST	nilotinib Sensitive: C3 – Early Trials
KIT exon 11 mutation KIT exon 11 mutation	Gastrointestinal Stromal Tumor GIST	sunitinib Sensitive: C3 – Early Trials
PDGFRA D842V PDGFRA D842V	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: C3 – Early Trials
CDK4 overexpression CDK4 overexpression	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: C3 – Early Trials
TP53 overexpression TP53 overexpression	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: C3 – Early Trials
MDM2 overexpression MDM2 overexpression	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: C3 – Early Trials
DEPDC5 deletion DEPDC5 deletion	Gastrointestinal Stromal Tumor GIST	imatinib + everolimus Sensitive: C3 – Early Trials
KIT exon 11 W557_K558delins KIT exon 11 W557_K558delins	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: C3 – Early Trials
KIT exon 17 mutation KIT exon 17 mutation	Gastrointestinal Stromal Tumor GIST	avapritinib Resistant: C4 – Case Studies
KIT exon 11 mutation KIT exon 11 mutation	Gastrointestinal Stromal Tumor GIST	avapritinib Resistant: C4 – Case Studies
KIT exon 9 mutation KIT exon 9 mutation	Gastrointestinal Stromal Tumor GIST	avapritinib Resistant: C4 – Case Studies
BRAF V600E BRAF V600E	Gastrointestinal Stromal Tumor GIST	sorafenib Resistant: C4 – Case Studies
PDGFRA mutation PDGFRA mutation	Gastrointestinal Stromal Tumor GIST	AZD1775 Sensitive: D – Preclinical
PDGFRA mutation PDGFRA mutation	Gastrointestinal Stromal Tumor GIST	AZD1775 + avapritinib Sensitive: D – Preclinical
KIT mutation KIT mutation	Gastrointestinal Stromal Tumor GIST	AZD1775 + avapritinib Sensitive: D – Preclinical
GPR20 expression GPR20 expression	Gastrointestinal Stromal Tumor GIST	DS-6157 Sensitive: D – Preclinical
KIT exon 11 mutation + KIT exon 17 mutation KIT exon 11 mutation + KIT exon 17 mutation	Gastrointestinal Stromal Tumor GIST	sunitinib + IPI 493 Sensitive: D – Preclinical
KIT exon 9 mutation KIT exon 9 mutation	Gastrointestinal Stromal Tumor GIST	IPI 493 Sensitive: D – Preclinical
KIT P577del + KIT W557Lfs5 + KIT Y823D KIT P577del + KIT W557Lfs5 + KIT Y823D	Gastrointestinal Stromal Tumor GIST	PM184 Sensitive: D – Preclinical
KIT P577del + KIT W557Lfs5 + KIT Y823D KIT P577del + KIT W557Lfs5 + KIT Y823D	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: D – Preclinical
KIT W557_V559delinsF KIT W557_V559delinsF	Gastrointestinal Stromal Tumor GIST	imatinib Sensitive: D – Preclinical
KIT W557_V559delinsF KIT W557_V559delinsF	Gastrointestinal Stromal Tumor GIST	PM184 Sensitive: D – Preclinical
FGF2-H FGF2-H	Gastrointestinal Stromal Tumor GIST	imatinib + infigratinib Sensitive: D – Preclinical
FGF2-H FGF2-H	Gastrointestinal Stromal Tumor GIST	imatinib Resistant: D – Preclinical

Gastrointestinal Stromal Tumor

Associations(76)

Associations
(76)