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DRUG CLASS:

PAK4 inhibitor

DRUG CLASS:

PAK4 inhibitor

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PAK4 overexpression	Solid Tumor	PAK4 overexpression	Solid Tumor	KPT-9274 + PD1 inhibitor Sensitive: D – Preclinical KPT-9274 + PD1 inhibitor Sensitive : D	KPT-9274 + PD1 inhibitor Sensitive: D – Preclinical KPT-9274 + PD1 inhibitor Sensitive : D
KRAS G12C	Non Small Cell Lung Cancer	KRAS G12C	Non Small Cell Lung Cancer	sotorasib + KPT-9274 Sensitive: D – Preclinical sotorasib + KPT-9274 Sensitive : D	sotorasib + KPT-9274 Sensitive: D – Preclinical sotorasib + KPT-9274 Sensitive : D
KRAS G12C	Pancreatic Ductal Adenocarcinoma	KRAS G12C	Pancreatic Ductal Adenocarcinoma	sotorasib + KPT-9274 Sensitive: D – Preclinical sotorasib + KPT-9274 Sensitive : D	sotorasib + KPT-9274 Sensitive: D – Preclinical sotorasib + KPT-9274 Sensitive : D