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    Association details:
    Biomarker:No biomarker
    Cancer:Ewing Sarcoma
    Drug:temozolomide (DNA synthesis inhibitor) +
    irinotecan (Topoisomerase I inhibitor) +
    vincristine (Tubulin polymerization inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    Source:
    NCCN
    Published date:
    11/20/2020
    Excerpt:
    Ewing sarcoma: Second-line therapy (relapsed/refractory or metastatic disease)…Preferred Regimens…Irinotecan + Temozolomide ± vincristine