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DRUG CLASS:

Nicotinamide phosphoribosyltransferase inhibitor

DRUG CLASS:

Nicotinamide phosphoribosyltransferase inhibitor

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News alerts, weekly reports and conference planners

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BCR-ABL1 T315I	Chronic Myeloid Leukemia	BCR-ABL1 T315I	Chronic Myeloid Leukemia	ponatinib + GMX1778 Sensitive: D – Preclinical ponatinib + GMX1778 Sensitive : D	ponatinib + GMX1778 Sensitive: D – Preclinical ponatinib + GMX1778 Sensitive : D
BCR-ABL1 fusion	Chronic Myeloid Leukemia	BCR-ABL1 fusion	Chronic Myeloid Leukemia	ponatinib + GMX1778 Sensitive: D – Preclinical ponatinib + GMX1778 Sensitive : D	ponatinib + GMX1778 Sensitive: D – Preclinical ponatinib + GMX1778 Sensitive : D
IDH2 mutation	Glioma	IDH2 mutation	Glioma	APO866 Sensitive: D – Preclinical APO866 Sensitive : D	APO866 Sensitive: D – Preclinical APO866 Sensitive : D
IDH1 mutation	Glioma	IDH1 mutation	Glioma	APO866 Sensitive: D – Preclinical APO866 Sensitive : D	APO866 Sensitive: D – Preclinical APO866 Sensitive : D
PAK4 overexpression	Solid Tumor	PAK4 overexpression	Solid Tumor	KPT-9274 + PD1 inhibitor Sensitive: D – Preclinical KPT-9274 + PD1 inhibitor Sensitive : D	KPT-9274 + PD1 inhibitor Sensitive: D – Preclinical KPT-9274 + PD1 inhibitor Sensitive : D
ARSI overexpression	Head and Neck Cancer	ARSI overexpression	Head and Neck Cancer	APO866 Resistant: D – Preclinical APO866 Resistant : D	APO866 Resistant: D – Preclinical APO866 Resistant : D
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KRAS G12C	Pancreatic Ductal Adenocarcinoma	KRAS G12C	Pancreatic Ductal Adenocarcinoma	sotorasib + KPT-9274 Sensitive: D – Preclinical sotorasib + KPT-9274 Sensitive : D	sotorasib + KPT-9274 Sensitive: D – Preclinical sotorasib + KPT-9274 Sensitive : D