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GENE:

MTHFR (Methylenetetrahydrofolate Reductase)

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MTHFR underexpression	Acute Myelogenous Leukemia	MTHFR underexpression	Acute Myelogenous Leukemia	OTX015 Sensitive: C3 – Early Trials OTX015 Sensitive : C3	OTX015 Sensitive: C3 – Early Trials OTX015 Sensitive : C3
MTHFR C677T	Colorectal Cancer	MTHFR C677T	Colorectal Cancer	5-fluorouracil + irinotecan Sensitive: C3 – Early Trials 5-fluorouracil + irinotecan Sensitive : C3	5-fluorouracil + irinotecan Sensitive: C3 – Early Trials 5-fluorouracil + irinotecan Sensitive : C3
MTHFR C677T	Colorectal Cancer	MTHFR C677T	Colorectal Cancer	5-fluorouracil + oxaliplatin Sensitive: C3 – Early Trials 5-fluorouracil + oxaliplatin Sensitive : C3	5-fluorouracil + oxaliplatin Sensitive: C3 – Early Trials 5-fluorouracil + oxaliplatin Sensitive : C3
MTHFR C677T	Colorectal Cancer	MTHFR C677T	Colorectal Cancer	capecitabine + irinotecan Sensitive: C3 – Early Trials capecitabine + irinotecan Sensitive : C3	capecitabine + irinotecan Sensitive: C3 – Early Trials capecitabine + irinotecan Sensitive : C3
MTHFR C677T	Colorectal Cancer	MTHFR C677T	Colorectal Cancer	capecitabine + oxaliplatin Sensitive: C3 – Early Trials capecitabine + oxaliplatin Sensitive : C3	capecitabine + oxaliplatin Sensitive: C3 – Early Trials capecitabine + oxaliplatin Sensitive : C3