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Association details:
| Biomarker: | MTHFR C677T |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | capecitabine (Thymidylate synthase inhibitor) + oxaliplatin (DNA synthesis inhibitor, DNA cross linking agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
C677T and A1298C MTHFR gene polymorphisms and response to fluoropyrimidine-based chemotherapy in Mestizo patients with metastatic colorectal cancer
Published date:
06/09/2021
Excerpt:
Patients received first-line therapy with capecitabine or 5-fluorouracil in combination with oxaliplatin or irinotecan...Patients carrying at least one mutant allele of the MTHFR C677T SNP had a better overall response and longer PFS than wild-type homozygous patients.
DOI:
10.1097/FPC.0000000000000440
