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BIOMARKER:

MSI-H/dMMR + TMB-H

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Related biomarkers:

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MSI-H/dMMR + KMT2D mutation (1)

MSI-H/dMMR + KMT2D mutation (1)

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MSI-H/dMMR + TMB-H	Colorectal Cancer	MSI-H/dMMR + TMB-H	Colorectal Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
MSI-H/dMMR + TMB-H	Solid Tumor	MSI-H/dMMR + TMB-H	Solid Tumor	pucotenlimab Sensitive: C3 – Early Trials pucotenlimab Sensitive : C3	pucotenlimab Sensitive: C3 – Early Trials pucotenlimab Sensitive : C3
MSI-H/dMMR + TMB-H	Solid Tumor	MSI-H/dMMR + TMB-H	Solid Tumor	atezolizumab Sensitive: C3 – Early Trials atezolizumab Sensitive : C3	atezolizumab Sensitive: C3 – Early Trials atezolizumab Sensitive : C3
MSI-H/dMMR + TMB-H	Prostate Cancer	MSI-H/dMMR + TMB-H	Prostate Cancer	avelumab Sensitive: C4 – Case Studies avelumab Sensitive : C4	avelumab Sensitive: C4 – Case Studies avelumab Sensitive : C4
MSI-H/dMMR + TMB-H	HER2 Positive Breast Cancer	MSI-H/dMMR + TMB-H	HER2 Positive Breast Cancer	pembrolizumab + trastuzumab Sensitive: C4 – Case Studies pembrolizumab + trastuzumab Sensitive : C4	pembrolizumab + trastuzumab Sensitive: C4 – Case Studies pembrolizumab + trastuzumab Sensitive : C4
MSI-H/dMMR + TMB-H	Pancreatic Adenocarcinoma	MSI-H/dMMR + TMB-H	Pancreatic Adenocarcinoma	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4
MSI-H/dMMR + TMB-H	Pancreatic Ductal Adenocarcinoma	MSI-H/dMMR + TMB-H	Pancreatic Ductal Adenocarcinoma	nivolumab + ipilimumab Sensitive: C4 – Case Studies nivolumab + ipilimumab Sensitive : C4	nivolumab + ipilimumab Sensitive: C4 – Case Studies nivolumab + ipilimumab Sensitive : C4
MSI-H/dMMR + TMB-H	Gastric Cancer	MSI-H/dMMR + TMB-H	Gastric Cancer	olaparib Sensitive: D – Preclinical olaparib Sensitive : D	olaparib Sensitive: D – Preclinical olaparib Sensitive : D