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Association details:
| Biomarker: | MSI-H/dMMR + TMB-H |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Lynparza (olaparib) (PARP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2055 - Evaluation of DNA damage repair gene alterations, microsatellite instability status, and tumor mutational burden as predictive biomarkers of olaparib sensitivity in gastric cancer
Published date:
03/10/2021
Excerpt:
MSI-H cell lines were sensitive to olaparib when it had high TMB.MSI status and TMB could predict olaparib sensitivity in gastric cancer...
