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BIOMARKER:

MSI-H/dMMR + BRAF Mutation

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Entrez ID:

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MSI-H/dMMR (182)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

MSI-H/dMMR + TMB-H (8)

MSI-H/dMMR + TMB-L (5)

PTEN mutation + MSI-H/dMMR (5)

MSI-H/dMMR + POLE mutation (4)

BRAF V600K + LDH elevation (3)

ARID1A mutation + MSI-H (3)

MSI-H/dMMR + MLH1 deletion + PMS2 deletion (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

MSI-L/dMMR + KRAS G12V (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

B2M mutation + MSI-H/dMMR (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

JAK1 mutation + MSI-H/dMMR (1)

JAK2 mutation + MSI-H/dMMR (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSH6 mutation + MLH1 mutation + MSI-H (1)

MSI-H + HER-2 amplification (1)

MSI-H + MSH2 expression + MSH6 expression (1)

MSI-H/dMMR + HER-2 mutation (1)

MSI-H/dMMR + KDR overexpression (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + MLH1 negative + PMS2 negative (1)

MSI-H/dMMR + NTRK1 fusion (1)

MSI-H/dMMR + NTRK2 fusion (1)

MSI-H/dMMR + NTRK3 fusion (1)

MSI-H/dMMR + PD-1 expression + CD8 positive (1)

MSI-H/dMMR + RAS mutation (1)

MSI-H/dMMR + TP53 mutation (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 expression + MSI-H/dMMR (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

PD-L1 overexpression + BRAF mutation (0)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

MSI-H/dMMR + RAS wild-type (0)

MSI-L/dMMR + SMAD4 mutation (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

MSI-H/dMMR (182)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

MSI-H/dMMR + TMB-H (8)

MSI-H/dMMR + TMB-L (5)

PTEN mutation + MSI-H/dMMR (5)

MSI-H/dMMR + POLE mutation (4)

BRAF V600K + LDH elevation (3)

ARID1A mutation + MSI-H (3)

MSI-H/dMMR + MLH1 deletion + PMS2 deletion (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

MSI-L/dMMR + KRAS G12V (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

B2M mutation + MSI-H/dMMR (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

JAK1 mutation + MSI-H/dMMR (1)

JAK2 mutation + MSI-H/dMMR (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSH6 mutation + MLH1 mutation + MSI-H (1)

MSI-H + HER-2 amplification (1)

MSI-H + MSH2 expression + MSH6 expression (1)

MSI-H/dMMR + HER-2 mutation (1)

MSI-H/dMMR + KDR overexpression (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + MLH1 negative + PMS2 negative (1)

MSI-H/dMMR + NTRK1 fusion (1)

MSI-H/dMMR + NTRK2 fusion (1)

MSI-H/dMMR + NTRK3 fusion (1)

MSI-H/dMMR + PD-1 expression + CD8 positive (1)

MSI-H/dMMR + RAS mutation (1)

MSI-H/dMMR + TP53 mutation (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 expression + MSI-H/dMMR (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

PD-L1 overexpression + BRAF mutation (0)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

MSI-H/dMMR + RAS wild-type (0)

MSI-L/dMMR + SMAD4 mutation (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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MSI-H/dMMR + BRAF Mutation

Colorectal Cancer

nivolumab + ipilimumab

Sensitive: C3 – Early Trials

nivolumab + ipilimumab

nivolumab + ipilimumab

Sensitive: C3 – Early Trials

nivolumab + ipilimumab