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BIOMARKER:

MLL rearrangement

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Other names: HTRX1, HTRX, MLL1A, Mixed Lineage Leukemia 1, Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 1, CXXC7, MLL1, TRX1, Zinc Finger Protein HRX, Trithorax-Like Protein, ALL-1, Lysine (K)-Specific Methyltransferase 2A, CXXC-Type Zinc Finger Protein 7, Histone-Lysine N-Methyltransferase 2A, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Lysine Methyltransferase 2A, MLL, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, KMT2A
MLL rearrangement
Acute Myelogenous Leukemia
palbociclib
Sensitive
:
C2
MLL rearrangement
Acute Myelogenous Leukemia
venetoclax
Sensitive
:
C2
MLL rearrangement
Acute Myelogenous Leukemia
abemaciclib
Sensitive
:
C3
MLL rearrangement
Acute Lymphocytic Leukemia
blinatumomab + inotuzumab ozogamicin
Resistant
:
C3
MLL rearrangement
Acute Lymphocytic Leukemia
inotuzumab ozogamicin
Resistant
:
C3
MLL rearrangement
Acute Myelogenous Leukemia
KO-539
Sensitive
:
C3
MLL rearrangement
B Acute Lymphoblastic Leukemia
blinatumomab
Resistant
:
C3
MLL rearrangement
Childhood B Acute Lymphoblastic Leukemia
MK-2206
Sensitive
:
D
MLL rearrangement
B Acute Lymphoblastic Leukemia
venetoclax
Sensitive
:
D
MLL rearrangement
Leukemia
JQ-1
Sensitive
:
D