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Association details:
| Biomarker: | MLL rearrangement |
|---|---|
| Cancer: | Leukemia |
| Drug: | JQ-1 (BET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of MYC and MAT2A promotes synergistic anti-leukemic effects in a human MLLr model and simultaneously augments iNKT-cell responses
Published date:
09/10/2020
Excerpt:
MLLr cells were treated with increasing concentrations of the BRD4 inhibitor JQ1 and PF-9366 (MAT2Ai) or their combination...A dose-dependent increase in apoptosis could be observed by utilizing both inhibitors alone or in combination leading to a synergistic effect (combination index (CI) of 0.75). Furthermore, inhibitor treatment led to decreased cell viability and reduced proliferation which was further augmented with the combination treatment.
