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Association details:
| Biomarker: | MLL-AFF1 fusion |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | Farydak (panobinostat) (HDAC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia
Excerpt:
...both at the mRNA and protein level, LBH589 completely neutralized the expression of the MLL–AF4 fusion within 48 h of exposure (Figures 5c and d)….
