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BIOMARKER:

MLL-AFF1 fusion

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Other names: HTRX1, HTRX, MLL1A, Mixed Lineage Leukemia 1, Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 1, CXXC7, MLL1, TRX1, Zinc Finger Protein HRX, Trithorax-Like Protein, ALL-1, Lysine (K)-Specific Methyltransferase 2A, CXXC-Type Zinc Finger Protein 7, Histone-Lysine N-Methyltransferase 2A, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Lysine Methyltransferase 2A, MLL, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, KMT2A, AFF1, AF4/FMR2 Family Member 1, ALL1-Fused Gene From Chromosome 4 Protein, Pre-B-C
Entrez ID:
Related biomarkers:
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Trials
MLL-AFF1 fusion
ALL
etoposide oral
Sensitive: B - Late Trials
MLL-AFF1 fusion
B Acute Lymphoblastic Leukemia
venetoclax
Sensitive: C3 – Early Trials
MLL-AFF1 fusion
ALL
ONX 0914
Sensitive: D – Preclinical
MLL-AFF1 fusion
ALL
panobinostat
Sensitive: D – Preclinical
MLL-AFF1 fusion
ALL
selumetinib + GS-9973
Sensitive: D – Preclinical
MLL-AFF1 fusion
ALL
GS-9973
Sensitive: D – Preclinical