^
Association details:
| Biomarker: | MGMT promoter methylation |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | metformin (AMPK activator) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing
Published date:
10/27/2023
Excerpt:
In this study, we assessed the association between metformin use and overall survival in glioblastoma patients….Metformin use was associated with longer survival in patients with tumors that had a methylated O6-methylguanine DNA methyltransferase gene (MGMT) promoter (484 days 95% CI: 56-911 vs. 394 days 95% CI: 249-538, Log-Rank test: 6.5, p = 0.01).
DOI:
10.1007/s11060-023-04485-2
