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BIOMARKER:
MET amplification
i
Other names:
DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MET amplification + EGFR mutation (8)
EGFR mutation + MET amplification (5)
ALK rearrangement + MET amplification (3)
EGFR mutation + MET overexpression (3)
MET amplification + MET Exon 14 mutation (3)
MET elevation (3)
MET overexpression + EGFR mutation (3)
BRAF mutation + MET amplification (2)
CD74-ROS1 fusion + MET D1228N + MET amplification (2)
EGFR exon 19 deletion + MET amplification (2)
EGFR exon 19 deletion + MET Amplification + MET D1228V (2)
MET amplification + MET overexpression (2)
PD-L1 overexpression + MET exon 14 mutation (2)
STRN-ALK fusion + MET amplification (2)
ALK rearrangement + MET amplification (1)
CAPZA2-MET fusion + MET amplification (1)
EGFR C797S + MET amplification (1)
EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)
EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)
EGFR L858R + MET amplification (1)
EGFR L858R + MET overexpression (1)
EGFR L858R + MET positive (1)
EGFR T263P + EGFR L858R + MET amplification (1)
EGFR T790M + MET amplification (1)
EGFR T790M + MET positive (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + MET positive (1)
EGFR exon 19 deletion + MET amplification (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
EGFR mutation + MET amplification + EGFR amplification (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + MET overexpression + MET amplification (1)
EGFR mutation + MET-CEP7 fusion (1)
EGFR wild-type + MET amplification (1)
EGFR wild-type + MET overexpression (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
KIAA1549-BRAF fusion + MET amplification (1)
KIF5B-RET fusion + MET amplification (1)
MET amplification + KLC1-ALK fusion (1)
MET amplification + MET exon 14 mutation + EGFR exon 20 insertion (1)
MET amplification + PIK3CA mutation (1)
MET amplification + RB1 wild-type (1)
MET amplification + RET fusion (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MET exon 14 mutation + ALK wild-type (1)
MET exon 14 mutation + EGFR wild-type (1)
MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)
MET exon 14 mutation + MET overexpression (1)
MET mutation + TMB-H (1)
MET negative + EGFR mutation (1)
MET overexpression + EGFR wild-type (1)
MET positive + EGFR mutation (1)
PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)
ROS1 positive + MET amplification (1)
TFE3 rearrangement + MET expression (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
MET-H (0)
MET amplification + EGFR mutation (8)
EGFR mutation + MET amplification (5)
ALK rearrangement + MET amplification (3)
EGFR mutation + MET overexpression (3)
MET amplification + MET Exon 14 mutation (3)
MET elevation (3)
MET overexpression + EGFR mutation (3)
BRAF mutation + MET amplification (2)
CD74-ROS1 fusion + MET D1228N + MET amplification (2)
EGFR exon 19 deletion + MET amplification (2)
EGFR exon 19 deletion + MET Amplification + MET D1228V (2)
MET amplification + MET overexpression (2)
PD-L1 overexpression + MET exon 14 mutation (2)
STRN-ALK fusion + MET amplification (2)
ALK rearrangement + MET amplification (1)
CAPZA2-MET fusion + MET amplification (1)
EGFR C797S + MET amplification (1)
EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)
EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)
EGFR L858R + MET amplification (1)
EGFR L858R + MET overexpression (1)
EGFR L858R + MET positive (1)
EGFR T263P + EGFR L858R + MET amplification (1)
EGFR T790M + MET amplification (1)
EGFR T790M + MET positive (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + MET positive (1)
EGFR exon 19 deletion + MET amplification (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
EGFR mutation + MET amplification + EGFR amplification (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + MET overexpression + MET amplification (1)
EGFR mutation + MET-CEP7 fusion (1)
EGFR wild-type + MET amplification (1)
EGFR wild-type + MET overexpression (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
KIAA1549-BRAF fusion + MET amplification (1)
KIF5B-RET fusion + MET amplification (1)
MET amplification + KLC1-ALK fusion (1)
MET amplification + MET exon 14 mutation + EGFR exon 20 insertion (1)
MET amplification + PIK3CA mutation (1)
MET amplification + RB1 wild-type (1)
MET amplification + RET fusion (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MET exon 14 mutation + ALK wild-type (1)
MET exon 14 mutation + EGFR wild-type (1)
MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)
MET exon 14 mutation + MET overexpression (1)
MET mutation + TMB-H (1)
MET negative + EGFR mutation (1)
MET overexpression + EGFR wild-type (1)
MET positive + EGFR mutation (1)
PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)
ROS1 positive + MET amplification (1)
TFE3 rearrangement + MET expression (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
MET-H (0)
›
Associations
News
Trials
VERI cancer hierarchy
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MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
tepotinib
Sensitive: A2 - Guideline
tepotinib
Sensitive
:
A2
tepotinib
Sensitive: A2 - Guideline
tepotinib
Sensitive
:
A2
MET amplification
Renal Cell Carcinoma
MET amplification
Renal Cell Carcinoma
savolitinib
Sensitive: A2 - Guideline
savolitinib
Sensitive
:
A2
savolitinib
Sensitive: A2 - Guideline
savolitinib
Sensitive
:
A2
MET amplification
Gastroesophageal Junction Adenocarcinoma
MET amplification
Gastroesophageal Junction Adenocarcinoma
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
MET amplification
Gastric Adenocarcinoma
MET amplification
Gastric Adenocarcinoma
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
bevacizumab + crizotinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + crizotinib
Sensitive
:
C2
bevacizumab + crizotinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + crizotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gumarontinib
Sensitive: C2 – Inclusion Criteria
gumarontinib
Sensitive
:
C2
gumarontinib
Sensitive: C2 – Inclusion Criteria
gumarontinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gefitinib + CT053PTSA
Sensitive: C2 – Inclusion Criteria
gefitinib + CT053PTSA
Sensitive
:
C2
gefitinib + CT053PTSA
Sensitive: C2 – Inclusion Criteria
gefitinib + CT053PTSA
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
osimertinib + savolitinib
Sensitive: C2 – Inclusion Criteria
osimertinib + savolitinib
Sensitive
:
C2
osimertinib + savolitinib
Sensitive: C2 – Inclusion Criteria
osimertinib + savolitinib
Sensitive
:
C2
MET amplification
Lung Cancer
MET amplification
Lung Cancer
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
APL-101
Sensitive: C2 – Inclusion Criteria
APL-101
Sensitive
:
C2
APL-101
Sensitive: C2 – Inclusion Criteria
APL-101
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
capmatinib
Sensitive: C2 – Inclusion Criteria
capmatinib
Sensitive
:
C2
capmatinib
Sensitive: C2 – Inclusion Criteria
capmatinib
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
MET amplification
Renal Cell Carcinoma
MET amplification
Renal Cell Carcinoma
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
MET amplification
Head and Neck Cancer
MET amplification
Head and Neck Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
REGN5093
Sensitive: C2 – Inclusion Criteria
REGN5093
Sensitive
:
C2
REGN5093
Sensitive: C2 – Inclusion Criteria
REGN5093
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
ABN401
Sensitive: C2 – Inclusion Criteria
ABN401
Sensitive
:
C2
ABN401
Sensitive: C2 – Inclusion Criteria
ABN401
Sensitive
:
C2
MET amplification
Solid Tumor
MET amplification
Solid Tumor
ABBV-400
Sensitive: C2 – Inclusion Criteria
ABBV-400
Sensitive
:
C2
ABBV-400
Sensitive: C2 – Inclusion Criteria
ABBV-400
Sensitive
:
C2
MET amplification
Gastric Adenocarcinoma
MET amplification
Gastric Adenocarcinoma
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
U3-1402
Sensitive: C3 – Early Trials
U3-1402
Sensitive
:
C3
U3-1402
Sensitive: C3 – Early Trials
U3-1402
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
MET amplification
Gallbladder Cancer
MET amplification
Gallbladder Cancer
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
c-MET inhibitor
Sensitive: C3 – Early Trials
c-MET inhibitor
Sensitive
:
C3
c-MET inhibitor
Sensitive: C3 – Early Trials
c-MET inhibitor
Sensitive
:
C3
MET amplification
Colorectal Cancer
MET amplification
Colorectal Cancer
TPX-0022
Sensitive: C3 – Early Trials
TPX-0022
Sensitive
:
C3
TPX-0022
Sensitive: C3 – Early Trials
TPX-0022
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gefitinib + savolitinib
Sensitive: C3 – Early Trials
gefitinib + savolitinib
Sensitive
:
C3
gefitinib + savolitinib
Sensitive: C3 – Early Trials
gefitinib + savolitinib
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
MET amplification
Solid Tumor
MET amplification
Solid Tumor
unecritinib
Sensitive: C3 – Early Trials
unecritinib
Sensitive
:
C3
unecritinib
Sensitive: C3 – Early Trials
unecritinib
Sensitive
:
C3
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
MET amplification
Lung Adenocarcinoma
MET amplification
Lung Adenocarcinoma
crizotinib + osimertinib
Sensitive: C3 – Early Trials
crizotinib + osimertinib
Sensitive
:
C3
crizotinib + osimertinib
Sensitive: C3 – Early Trials
crizotinib + osimertinib
Sensitive
:
C3
^
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