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BIOMARKER:
MET amplification
i
Other names:
DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MET exon 14 mutation (33)
MET mutation (13)
MET H1094Y (3)
MET N375S (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
MET exon 14 mutation (33)
MET mutation (13)
MET H1094Y (3)
MET N375S (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
›
Associations
News
Trials
VERI cancer hierarchy
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MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
tepotinib
Sensitive: A2 - Guideline
tepotinib
Sensitive
:
A2
tepotinib
Sensitive: A2 - Guideline
tepotinib
Sensitive
:
A2
MET amplification
Renal Cell Carcinoma
MET amplification
Renal Cell Carcinoma
savolitinib
Sensitive: A2 - Guideline
savolitinib
Sensitive
:
A2
savolitinib
Sensitive: A2 - Guideline
savolitinib
Sensitive
:
A2
MET amplification
Gastroesophageal Junction Adenocarcinoma
MET amplification
Gastroesophageal Junction Adenocarcinoma
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
MET amplification
Gastric Adenocarcinoma
MET amplification
Gastric Adenocarcinoma
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
bevacizumab + crizotinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + crizotinib
Sensitive
:
C2
bevacizumab + crizotinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + crizotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gumarontinib
Sensitive: C2 – Inclusion Criteria
gumarontinib
Sensitive
:
C2
gumarontinib
Sensitive: C2 – Inclusion Criteria
gumarontinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gefitinib + CT053PTSA
Sensitive: C2 – Inclusion Criteria
gefitinib + CT053PTSA
Sensitive
:
C2
gefitinib + CT053PTSA
Sensitive: C2 – Inclusion Criteria
gefitinib + CT053PTSA
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
osimertinib + savolitinib
Sensitive: C2 – Inclusion Criteria
osimertinib + savolitinib
Sensitive
:
C2
osimertinib + savolitinib
Sensitive: C2 – Inclusion Criteria
osimertinib + savolitinib
Sensitive
:
C2
MET amplification
Lung Cancer
MET amplification
Lung Cancer
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
APL-101
Sensitive: C2 – Inclusion Criteria
APL-101
Sensitive
:
C2
APL-101
Sensitive: C2 – Inclusion Criteria
APL-101
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
capmatinib
Sensitive: C2 – Inclusion Criteria
capmatinib
Sensitive
:
C2
capmatinib
Sensitive: C2 – Inclusion Criteria
capmatinib
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
MET amplification
Renal Cell Carcinoma
MET amplification
Renal Cell Carcinoma
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
MET amplification
Head and Neck Cancer
MET amplification
Head and Neck Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
REGN5093
Sensitive: C2 – Inclusion Criteria
REGN5093
Sensitive
:
C2
REGN5093
Sensitive: C2 – Inclusion Criteria
REGN5093
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
savolitinib
Sensitive: C2 – Inclusion Criteria
savolitinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
ABN401
Sensitive: C2 – Inclusion Criteria
ABN401
Sensitive
:
C2
ABN401
Sensitive: C2 – Inclusion Criteria
ABN401
Sensitive
:
C2
MET amplification
Solid Tumor
MET amplification
Solid Tumor
ABBV-400
Sensitive: C2 – Inclusion Criteria
ABBV-400
Sensitive
:
C2
ABBV-400
Sensitive: C2 – Inclusion Criteria
ABBV-400
Sensitive
:
C2
MET amplification
Gastric Adenocarcinoma
MET amplification
Gastric Adenocarcinoma
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
U3-1402
Sensitive: C3 – Early Trials
U3-1402
Sensitive
:
C3
U3-1402
Sensitive: C3 – Early Trials
U3-1402
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
MET amplification
Gallbladder Cancer
MET amplification
Gallbladder Cancer
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
c-MET inhibitor
Sensitive: C3 – Early Trials
c-MET inhibitor
Sensitive
:
C3
c-MET inhibitor
Sensitive: C3 – Early Trials
c-MET inhibitor
Sensitive
:
C3
MET amplification
Colorectal Cancer
MET amplification
Colorectal Cancer
TPX-0022
Sensitive: C3 – Early Trials
TPX-0022
Sensitive
:
C3
TPX-0022
Sensitive: C3 – Early Trials
TPX-0022
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gefitinib + savolitinib
Sensitive: C3 – Early Trials
gefitinib + savolitinib
Sensitive
:
C3
gefitinib + savolitinib
Sensitive: C3 – Early Trials
gefitinib + savolitinib
Sensitive
:
C3
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
MET amplification
Solid Tumor
MET amplification
Solid Tumor
unecritinib
Sensitive: C3 – Early Trials
unecritinib
Sensitive
:
C3
unecritinib
Sensitive: C3 – Early Trials
unecritinib
Sensitive
:
C3
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
MET amplification
Lung Adenocarcinoma
MET amplification
Lung Adenocarcinoma
crizotinib + osimertinib
Sensitive: C3 – Early Trials
crizotinib + osimertinib
Sensitive
:
C3
crizotinib + osimertinib
Sensitive: C3 – Early Trials
crizotinib + osimertinib
Sensitive
:
C3
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