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BIOMARKER:
MET amplification
i
Other names:
DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MET exon 14 mutation (33)
MET mutation (13)
MET H1094Y (3)
MET N375S (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
MET exon 14 mutation (33)
MET mutation (13)
MET H1094Y (3)
MET N375S (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
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Associations
News
Trials
VERI cancer hierarchy
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MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
tepotinib
Sensitive: A2 - Guideline
tepotinib
Sensitive
:
A2
tepotinib
Sensitive: A2 - Guideline
tepotinib
Sensitive
:
A2
MET amplification
Renal Cell Carcinoma
MET amplification
Renal Cell Carcinoma
savolitinib
Sensitive: A2 - Guideline
savolitinib
Sensitive
:
A2
savolitinib
Sensitive: A2 - Guideline
savolitinib
Sensitive
:
A2
MET amplification
Gastroesophageal Junction Adenocarcinoma
MET amplification
Gastroesophageal Junction Adenocarcinoma
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
MET amplification
Gastric Adenocarcinoma
MET amplification
Gastric Adenocarcinoma
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
AMG 102
Resistant: B - Late Trials
AMG 102
Resistant
:
B
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
bevacizumab + crizotinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + crizotinib
Sensitive
:
C2
bevacizumab + crizotinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + crizotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gumarontinib
Sensitive: C2 – Inclusion Criteria
gumarontinib
Sensitive
:
C2
gumarontinib
Sensitive: C2 – Inclusion Criteria
gumarontinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
gefitinib + CT053PTSA
Sensitive: C2 – Inclusion Criteria
gefitinib + CT053PTSA
Sensitive
:
C2
gefitinib + CT053PTSA
Sensitive: C2 – Inclusion Criteria
gefitinib + CT053PTSA
Sensitive
:
C2
MET amplification
Gastric Cancer
MET amplification
Gastric Cancer
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
osimertinib + savolitinib
Sensitive: C2 – Inclusion Criteria
osimertinib + savolitinib
Sensitive
:
C2
osimertinib + savolitinib
Sensitive: C2 – Inclusion Criteria
osimertinib + savolitinib
Sensitive
:
C2
MET amplification
Lung Cancer
MET amplification
Lung Cancer
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
tepotinib
Sensitive: C2 – Inclusion Criteria
tepotinib
Sensitive
:
C2
MET amplification
Non Small Cell Lung Cancer
MET amplification
Non Small Cell Lung Cancer
APL-101
Sensitive: C2 – Inclusion Criteria
APL-101
Sensitive
:
C2
APL-101
Sensitive: C2 – Inclusion Criteria
APL-101
Sensitive
:
C2
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