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DRUG:

cladribine

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Company:

Generic mfg.

Drug class:

Purinergic receptor P1 agonist

No biomarker	Hairy Cell Leukemia	No biomarker	Hairy Cell Leukemia	cladribine Sensitive: A1 - Approval cladribine Sensitive : A1	cladribine Sensitive: A1 - Approval cladribine Sensitive : A1
No biomarker	Waldenstrom Macroglobulinemia	No biomarker	Waldenstrom Macroglobulinemia	cladribine Sensitive: A2 - Guideline cladribine Sensitive : A2	cladribine Sensitive: A2 - Guideline cladribine Sensitive : A2
No biomarker	Acute Myelogenous Leukemia	No biomarker	Acute Myelogenous Leukemia	cytarabine + cladribine + Nugraf (filgrastim biosimilar) Sensitive: A2 - Guideline cytarabine + cladribine + Nugraf (filgrastim biosimilar) Sensitive : A2	cytarabine + cladribine + Nugraf (filgrastim biosimilar) Sensitive: A2 - Guideline cytarabine + cladribine + Nugraf (filgrastim biosimilar) Sensitive : A2
No biomarker	Acute Myelogenous Leukemia	No biomarker	Acute Myelogenous Leukemia	cytarabine + idarubicin hydrochloride + cladribine + Nugraf (filgrastim biosimilar) Sensitive: A2 - Guideline cytarabine + idarubicin hydrochloride + cladribine + Nugraf (filgrastim biosimilar) Sensitive : A2	cytarabine + idarubicin hydrochloride + cladribine + Nugraf (filgrastim biosimilar) Sensitive: A2 - Guideline cytarabine + idarubicin hydrochloride + cladribine + Nugraf (filgrastim biosimilar) Sensitive : A2
No biomarker	Acute Myelogenous Leukemia	No biomarker	Acute Myelogenous Leukemia	cytarabine + mitoxantrone + cladribine + Nugraf (filgrastim biosimilar) Sensitive: A2 - Guideline cytarabine + mitoxantrone + cladribine + Nugraf (filgrastim biosimilar) Sensitive : A2	cytarabine + mitoxantrone + cladribine + Nugraf (filgrastim biosimilar) Sensitive: A2 - Guideline cytarabine + mitoxantrone + cladribine + Nugraf (filgrastim biosimilar) Sensitive : A2
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3
FLT3 mutation	Acute Myelogenous Leukemia	FLT3 mutation	Acute Myelogenous Leukemia	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3
FLT3 mutation	Acute Myelogenous Leukemia	FLT3 mutation	Acute Myelogenous Leukemia	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3
IDH2 mutation	Acute Myelogenous Leukemia	IDH2 mutation	Acute Myelogenous Leukemia	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3
IDH2 mutation	Acute Myelogenous Leukemia	IDH2 mutation	Acute Myelogenous Leukemia	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3
RUNX1 mutation	Acute Myelogenous Leukemia	RUNX1 mutation	Acute Myelogenous Leukemia	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3	cytarabine + cladribine Sensitive: C3 – Early Trials cytarabine + cladribine Sensitive : C3
RUNX1 mutation	Acute Myelogenous Leukemia	RUNX1 mutation	Acute Myelogenous Leukemia	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3	decitabine + cladribine Sensitive: C3 – Early Trials decitabine + cladribine Sensitive : C3
TP53 mutation	Hairy Cell Leukemia	TP53 mutation	Hairy Cell Leukemia	rituximab + cladribine Resistant: C3 – Early Trials rituximab + cladribine Resistant : C3	rituximab + cladribine Resistant: C3 – Early Trials rituximab + cladribine Resistant : C3