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Association details:
| Biomarker: | LDH elevation |
|---|---|
| Cancer: | Lymphoma |
| Drug: | Yescarta (axicabtagene ciloleucel) (CD19-targeted CAR-T immunotherapy) |
| Direction: | Resistant |
Evidence:
Source:
Title:
244 - Absolute Monocytes Count and Clinical Outcome Predictors after CAR T Therapy for Relapsed/ Refractory Large B Cell Lymphoma
Published date:
02/11/2022
Excerpt:
This study cohort consist 49 patients received commercial Axicabtagene Ciloleucel (Axi-Cel)...Elevated LDH prior to lymphocytes collection was associated with decreased 1-yr overall survival (OS) (HR 7.71 (1.76, 33.85), p=0.0068).... Elevated LDH before lymphocytes collection is a marker for poor long-term survival.
