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Association details:
| Biomarker: | KRAS G12C |
|---|---|
| Cancer: | Pancreatic Ductal Adenocarcinoma |
| Drug: | Xpovio (selinexor) (XPO1 inhibitor) + MRTX1257 (KRAS inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1058 - Inhibition of nuclear transport protein XPO1 potentiates the effect of KRAS G12C inhibitors
Published date:
03/10/2021
Excerpt:
MRTX1257 and AMG510, when combined with KPT-330, synergistically inhibited (Combination Index values less than 1) the proliferation of KRASG12C mutant cancer cell lines, namely MiaPaCa-2 (PDAC) and NCI-H2122 (NSCLC).
