We investigated the frequency of KARS G12C in resected 877 lung adenocarcinoma and 113 squamous cell carcinoma cases by ddPCR. The combination effect of KRAS inhibitor and mTOR inhibitor in lung KRAS G12C positive adenocarcinoma cell line (H23) and squamous cell carcinoma cell line (Calu-1)....We utilized three KRAS inhibitors (AMG-510, MRTX849, and ARS-1620) and mTOR inhibitor (Everolimus)....Combination index ranged 0.386-0.717 and 0.278-0.648 in MTS assay and Colony forming assay, respectively; in both cell lines, the combination of each KRAS inhibitor and Everolimus showed synergism. The cell growth was suppressed by dose-dependent manner...