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Association details:
| Biomarker: | KRAS G12C |
|---|---|
| Cancer: | Gastrointestinal Cancer |
| Drug: | Lumakras (sotorasib) (KRAS G12C inhibitor) + AbGn-107 (Microtubule inhibitor, AG7-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
AMG 510, AbGn-107 Prove to Be Effective, Tolerable in GI Cancers
Published date:
07/11/2020
Excerpt:
The novel KRAS G12C inhibitor AMG 510, along with the antibody-drug conjugate (ADC), AbGn-107, have demonstrated efficacy and tolerability in early-phase studies of patients with KRAS G12C-mutated colorectal cancer (CRC) and gastrointestinal (GI) cancers, respectively, according to Andrew L. Coveler, MD
