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Association details:
| Biomarker: | KIT mutation |
|---|---|
| Cancer: | Gastrointestinal Stromal Tumor |
| Drug: | adavosertib (AZD1775) (WEE1 inhibitor) + Ayvakit (avapritinib) (CSF-1R inhibitor, PDGFR antagonist, mutant c-KIT inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of Wee1 as target in combination with avapritinib for Gastrointestinal Stromal Tumor treatment
Published date:
12/15/2020
Excerpt:
In vitro and in vivo studies revealed significant efficacy of MK-1775 (Wee1 inhibitor) in combination with avapritinib in KIT and PDGFRA-mutant GIST cell lines...
DOI:
10.1172/jci.insight.143474
