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BIOMARKER:

KIT mutation

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Other names: KIT, C-Kit, CD117, PBT, SCFR, Stem Cell Factor Receptor, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Entrez ID:
KIT mutation
Thymic Carcinoma
sunitinib
Sensitive: A2 - Guideline
KIT mutation
GIST
ripretinib
Sensitive: B - Late Trials
KIT mutation
GIST
TAS-116
Sensitive: B - Late Trials
KIT mutation
GIST
avapritinib
Sensitive: C2 – Inclusion Criteria
KIT mutation
GIST
imatinib
Sensitive: C2 – Inclusion Criteria
KIT mutation
Melanoma
imatinib
Sensitive: C2 – Inclusion Criteria
KIT mutation
Melanoma
sunitinib
Sensitive: C2 – Inclusion Criteria
KIT mutation
Melanoma
nivolumab
Sensitive: C2 – Inclusion Criteria
KIT mutation
GIST
sunitinib + PLX9486
Sensitive: C3 – Early Trials
KIT mutation
AML
LY3009120
Sensitive: C3 – Early Trials
KIT mutation
Mucosal Melanoma
PD1 inhibitor
Sensitive: C3 – Early Trials
KIT mutation
AML
ivosidenib
Resistant: C3 – Early Trials
KIT mutation
Mucosal Melanoma
cisplatin + temozolomide
Sensitive: C3 – Early Trials
KIT mutation
Mucosal Melanoma
cisplatin + dacarbazine
Sensitive: C3 – Early Trials
KIT mutation
Cutaneous Melanoma
PD1 inhibitor
Sensitive: C3 – Early Trials
KIT mutation
Melanoma
ripretinib
Sensitive: C3 – Early Trials
KIT mutation
GIST
AZD1775 + avapritinib
Sensitive: D – Preclinical
KIT mutation
AML
cabozantinib tablet
Sensitive: D – Preclinical