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BIOMARKER:
KIT mutation
i
Other names:
KIT, C-Kit, CD117, PBT, SCFR, Stem Cell Factor Receptor, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
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Entrez ID:
3815
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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KIT fusion (1)
KIT fusion (1)
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Associations
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VERI cancer hierarchy
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KIT mutation
Thymic Carcinoma
KIT mutation
Thymic Carcinoma
sunitinib
Sensitive: A2 - Guideline
sunitinib
Sensitive
:
A2
sunitinib
Sensitive: A2 - Guideline
sunitinib
Sensitive
:
A2
KIT mutation
Gastrointestinal Stromal Tumor
KIT mutation
Gastrointestinal Stromal Tumor
imatinib
Sensitive: A2 - Guideline
imatinib
Sensitive
:
A2
imatinib
Sensitive: A2 - Guideline
imatinib
Sensitive
:
A2
KIT mutation
Cutaneous Melanoma
KIT mutation
Cutaneous Melanoma
imatinib
Sensitive: A2 - Guideline
imatinib
Sensitive
:
A2
imatinib
Sensitive: A2 - Guideline
imatinib
Sensitive
:
A2
KIT mutation
Gastrointestinal Stromal Tumor
KIT mutation
Gastrointestinal Stromal Tumor
ripretinib
Sensitive: B - Late Trials
ripretinib
Sensitive
:
B
ripretinib
Sensitive: B - Late Trials
ripretinib
Sensitive
:
B
KIT mutation
Gastrointestinal Stromal Tumor
KIT mutation
Gastrointestinal Stromal Tumor
pimitespib
Sensitive: B - Late Trials
pimitespib
Sensitive
:
B
pimitespib
Sensitive: B - Late Trials
pimitespib
Sensitive
:
B
KIT mutation
Gastrointestinal Stromal Tumor
KIT mutation
Gastrointestinal Stromal Tumor
avapritinib
Sensitive: C2 – Inclusion Criteria
avapritinib
Sensitive
:
C2
avapritinib
Sensitive: C2 – Inclusion Criteria
avapritinib
Sensitive
:
C2
KIT mutation
Melanoma
KIT mutation
Melanoma
imatinib
Sensitive: C2 – Inclusion Criteria
imatinib
Sensitive
:
C2
imatinib
Sensitive: C2 – Inclusion Criteria
imatinib
Sensitive
:
C2
KIT mutation
Melanoma
KIT mutation
Melanoma
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
KIT mutation
Melanoma
KIT mutation
Melanoma
nivolumab
Sensitive: C2 – Inclusion Criteria
nivolumab
Sensitive
:
C2
nivolumab
Sensitive: C2 – Inclusion Criteria
nivolumab
Sensitive
:
C2
KIT mutation
Melanoma
KIT mutation
Melanoma
regorafenib
Sensitive: C2 – Inclusion Criteria
regorafenib
Sensitive
:
C2
regorafenib
Sensitive: C2 – Inclusion Criteria
regorafenib
Sensitive
:
C2
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
avapritinib
Sensitive: C2 – Inclusion Criteria
avapritinib
Sensitive
:
C2
avapritinib
Sensitive: C2 – Inclusion Criteria
avapritinib
Sensitive
:
C2
KIT mutation
Gastrointestinal Stromal Tumor
KIT mutation
Gastrointestinal Stromal Tumor
sunitinib + PLX9486
Sensitive: C3 – Early Trials
sunitinib + PLX9486
Sensitive
:
C3
sunitinib + PLX9486
Sensitive: C3 – Early Trials
sunitinib + PLX9486
Sensitive
:
C3
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
LY3009120
Sensitive: C3 – Early Trials
LY3009120
Sensitive
:
C3
LY3009120
Sensitive: C3 – Early Trials
LY3009120
Sensitive
:
C3
KIT mutation
Mucosal Melanoma
KIT mutation
Mucosal Melanoma
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
ivosidenib
Resistant: C3 – Early Trials
ivosidenib
Resistant
:
C3
ivosidenib
Resistant: C3 – Early Trials
ivosidenib
Resistant
:
C3
KIT mutation
Mucosal Melanoma
KIT mutation
Mucosal Melanoma
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
KIT mutation
Mucosal Melanoma
KIT mutation
Mucosal Melanoma
cisplatin + dacarbazine
Sensitive: C3 – Early Trials
cisplatin + dacarbazine
Sensitive
:
C3
cisplatin + dacarbazine
Sensitive: C3 – Early Trials
cisplatin + dacarbazine
Sensitive
:
C3
KIT mutation
Cutaneous Melanoma
KIT mutation
Cutaneous Melanoma
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
KIT mutation
Melanoma
KIT mutation
Melanoma
ripretinib
Sensitive: C3 – Early Trials
ripretinib
Sensitive
:
C3
ripretinib
Sensitive: C3 – Early Trials
ripretinib
Sensitive
:
C3
KIT mutation
Melanoma
KIT mutation
Melanoma
temozolomide + rivoceranib
Sensitive: C3 – Early Trials
temozolomide + rivoceranib
Sensitive
:
C3
temozolomide + rivoceranib
Sensitive: C3 – Early Trials
temozolomide + rivoceranib
Sensitive
:
C3
KIT mutation
Melanoma
KIT mutation
Melanoma
imatinib + toripalimab-tpzi
Sensitive: C3 – Early Trials
imatinib + toripalimab-tpzi
Sensitive
:
C3
imatinib + toripalimab-tpzi
Sensitive: C3 – Early Trials
imatinib + toripalimab-tpzi
Sensitive
:
C3
KIT mutation
Non Small Cell Lung Cancer
KIT mutation
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
azacitidine
Sensitive: C3 – Early Trials
azacitidine
Sensitive
:
C3
azacitidine
Sensitive: C3 – Early Trials
azacitidine
Sensitive
:
C3
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
azacitidine
Sensitive: C3 – Early Trials
azacitidine
Sensitive
:
C3
azacitidine
Sensitive: C3 – Early Trials
azacitidine
Sensitive
:
C3
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
azacitidine
Sensitive: C3 – Early Trials
azacitidine
Sensitive
:
C3
azacitidine
Sensitive: C3 – Early Trials
azacitidine
Sensitive
:
C3
KIT mutation
Non Small Cell Lung Cancer
KIT mutation
Non Small Cell Lung Cancer
PD1 inhibitor
Resistant: C3 – Early Trials
PD1 inhibitor
Resistant
:
C3
PD1 inhibitor
Resistant: C3 – Early Trials
PD1 inhibitor
Resistant
:
C3
KIT mutation
Prostate Cancer
KIT mutation
Prostate Cancer
enzalutamide
Resistant: C3 – Early Trials
enzalutamide
Resistant
:
C3
enzalutamide
Resistant: C3 – Early Trials
enzalutamide
Resistant
:
C3
KIT mutation
Prostate Cancer
KIT mutation
Prostate Cancer
enzalutamide + abiraterone acetate
Resistant: C3 – Early Trials
enzalutamide + abiraterone acetate
Resistant
:
C3
enzalutamide + abiraterone acetate
Resistant: C3 – Early Trials
enzalutamide + abiraterone acetate
Resistant
:
C3
KIT mutation
Prostate Cancer
KIT mutation
Prostate Cancer
abiraterone acetate
Resistant: C3 – Early Trials
abiraterone acetate
Resistant
:
C3
abiraterone acetate
Resistant: C3 – Early Trials
abiraterone acetate
Resistant
:
C3
KIT mutation
Melanoma
KIT mutation
Melanoma
PD1 inhibitor
Resistant: C3 – Early Trials
PD1 inhibitor
Resistant
:
C3
PD1 inhibitor
Resistant: C3 – Early Trials
PD1 inhibitor
Resistant
:
C3
KIT mutation
Gastrointestinal Stromal Tumor
KIT mutation
Gastrointestinal Stromal Tumor
AZD1775 + avapritinib
Sensitive: D – Preclinical
AZD1775 + avapritinib
Sensitive
:
D
AZD1775 + avapritinib
Sensitive: D – Preclinical
AZD1775 + avapritinib
Sensitive
:
D
KIT mutation
Acute Myelogenous Leukemia
KIT mutation
Acute Myelogenous Leukemia
cabozantinib tablet
Sensitive: D – Preclinical
cabozantinib tablet
Sensitive
:
D
cabozantinib tablet
Sensitive: D – Preclinical
cabozantinib tablet
Sensitive
:
D
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