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Association details:
| Biomarker: | IDH1 mutation |
|---|---|
| Cancer: | Cholangiocarcinoma |
| Drug: | metformin (AMPK activator) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors
Published date:
05/19/2021
Excerpt:
Patients with IDH1-mutated chondrosarcoma, glioma and intrahepatic cholangiocarcinoma received oral combinational treatment with the antidiabetic drug metformin and the antimalarial drug chloroquine…Of twelve evaluable patients, 10 patients discontinued study medication because of progressive disease...Treatment of advanced IDH1-mutated solid tumors with metformin and chloroquine was well tolerated but did not induce a clinical response...
Secondary therapy:
chloroquine phosphate
DOI:
10.3390/cancers13102474
