Patients received AZA 100mg on D1-7, VEN 200mg on D1-14, and CHI 30mg biweekly...Pretreatment IDH1 and IDH2 mutations were associated with higher CRc rates (75% and 50%, respectively). The CRc rate in patients with TP53 mutations was 67%, with response noted among patients with concurrent IDH1/IDH2 mutations...The combination of VEN and CHI plus AZA (VCA) demonstrated manageable safety and encouraging efficacy in patients with R/R AML. IDH1/IDH2 mutations were associated with the sensitivity of VCA, even in some patients with concurrent TP53 mutations.