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DRUG CLASS:

HDAC2 inhibitor

DRUG CLASS:

HDAC2 inhibitor

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HR positive	HER2 Negative Breast Cancer	HR positive	HER2 Negative Breast Cancer	entinostat Resistant: B - Late Trials entinostat Resistant : B	entinostat Resistant: B - Late Trials entinostat Resistant : B
HR positive	Breast Cancer	HR positive	Breast Cancer	entinostat Sensitive: C2 – Inclusion Criteria entinostat Sensitive : C2	entinostat Sensitive: C2 – Inclusion Criteria entinostat Sensitive : C2
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	entinostat Sensitive: C2 – Inclusion Criteria entinostat Sensitive : C2	entinostat Sensitive: C2 – Inclusion Criteria entinostat Sensitive : C2
IFNG gene signature overexpression	Melanoma	IFNG gene signature overexpression	Melanoma	nivolumab + 4SC-202 Sensitive: C3 – Early Trials nivolumab + 4SC-202 Sensitive : C3	nivolumab + 4SC-202 Sensitive: C3 – Early Trials nivolumab + 4SC-202 Sensitive : C3
LDH-L	Uveal Melanoma	LDH-L	Uveal Melanoma	pembrolizumab + entinostat Sensitive: C3 – Early Trials pembrolizumab + entinostat Sensitive : C3	pembrolizumab + entinostat Sensitive: C3 – Early Trials pembrolizumab + entinostat Sensitive : C3
HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	entinostat Sensitive: D – Preclinical entinostat Sensitive : D	entinostat Sensitive: D – Preclinical entinostat Sensitive : D
FBXW7 mutation	Squamous Cell Carcinoma of Head and Neck	FBXW7 mutation	Squamous Cell Carcinoma of Head and Neck	entinostat Sensitive: D – Preclinical entinostat Sensitive : D	entinostat Sensitive: D – Preclinical entinostat Sensitive : D
PAX3-FOXO1 fusion	Rhabdomyosarcoma	PAX3-FOXO1 fusion	Rhabdomyosarcoma	entinostat Sensitive: D – Preclinical entinostat Sensitive : D	entinostat Sensitive: D – Preclinical entinostat Sensitive : D
CDH1 deletion	Breast Cancer	CDH1 deletion	Breast Cancer	entinostat Sensitive: D – Preclinical entinostat Sensitive : D	entinostat Sensitive: D – Preclinical entinostat Sensitive : D
CDH1 deletion	Gastric Cancer	CDH1 deletion	Gastric Cancer	entinostat Sensitive: D – Preclinical entinostat Sensitive : D	entinostat Sensitive: D – Preclinical entinostat Sensitive : D