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DRUG CLASS:
HDAC2 inhibitor
DRUG CLASS:
HDAC2 inhibitor
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News alerts, weekly reports and conference planners
Related drugs:
‹
chidamide (23)
entinostat (9)
4SC-202 (1)
chidamide (23)
entinostat (9)
4SC-202 (1)
›
Associations
(33)
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Trials
VERI cancer hierarchy
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BCL2 expression + MYC expression
Diffuse Large B Cell Lymphoma
BCL2 expression + MYC expression
Diffuse Large B Cell Lymphoma
chidamide
Sensitive: A1 - Approval
chidamide
Sensitive
:
A1
chidamide
Sensitive: A1 - Approval
chidamide
Sensitive
:
A1
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
entinostat
Resistant: B - Late Trials
entinostat
Resistant
:
B
entinostat
Resistant: B - Late Trials
entinostat
Resistant
:
B
HR positive
HER2 Negative Breast Cancer
HR positive
HER2 Negative Breast Cancer
chidamide
Sensitive: B - Late Trials
chidamide
Sensitive
:
B
chidamide
Sensitive: B - Late Trials
chidamide
Sensitive
:
B
HR positive
Breast Cancer
HR positive
Breast Cancer
entinostat
Sensitive: C2 – Inclusion Criteria
entinostat
Sensitive
:
C2
entinostat
Sensitive: C2 – Inclusion Criteria
entinostat
Sensitive
:
C2
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
entinostat
Sensitive: C2 – Inclusion Criteria
entinostat
Sensitive
:
C2
entinostat
Sensitive: C2 – Inclusion Criteria
entinostat
Sensitive
:
C2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
chidamide
Sensitive: C2 – Inclusion Criteria
chidamide
Sensitive
:
C2
chidamide
Sensitive: C2 – Inclusion Criteria
chidamide
Sensitive
:
C2
KMT2D mutation
Diffuse Large B Cell Lymphoma
KMT2D mutation
Diffuse Large B Cell Lymphoma
chidamide
Resistant: C3 – Early Trials
chidamide
Resistant
:
C3
chidamide
Resistant: C3 – Early Trials
chidamide
Resistant
:
C3
HDAC1 amplification
Soft Tissue Sarcoma
HDAC1 amplification
Soft Tissue Sarcoma
PD1 inhibitor + chidamide
Sensitive: C3 – Early Trials
PD1 inhibitor + chidamide
Sensitive
:
C3
PD1 inhibitor + chidamide
Sensitive: C3 – Early Trials
PD1 inhibitor + chidamide
Sensitive
:
C3
TNFRSF8 negative
Peripheral T-cell Lymphoma
TNFRSF8 negative
Peripheral T-cell Lymphoma
chidamide
Sensitive: C3 – Early Trials
chidamide
Sensitive
:
C3
chidamide
Sensitive: C3 – Early Trials
chidamide
Sensitive
:
C3
PD-L1 expression
Non-Hodgkin’s Lymphoma
PD-L1 expression
Non-Hodgkin’s Lymphoma
sintilimab + chidamide
Sensitive: C3 – Early Trials
sintilimab + chidamide
Sensitive
:
C3
sintilimab + chidamide
Sensitive: C3 – Early Trials
sintilimab + chidamide
Sensitive
:
C3
IFNG gene signature overexpression
Melanoma
IFNG gene signature overexpression
Melanoma
nivolumab + 4SC-202
Sensitive: C3 – Early Trials
nivolumab + 4SC-202
Sensitive
:
C3
nivolumab + 4SC-202
Sensitive: C3 – Early Trials
nivolumab + 4SC-202
Sensitive
:
C3
LDH-L
Uveal Melanoma
LDH-L
Uveal Melanoma
pembrolizumab + entinostat
Sensitive: C3 – Early Trials
pembrolizumab + entinostat
Sensitive
:
C3
pembrolizumab + entinostat
Sensitive: C3 – Early Trials
pembrolizumab + entinostat
Sensitive
:
C3
IDH2 mutation + TP53 mutation
Acute Myelogenous Leukemia
IDH2 mutation + TP53 mutation
Acute Myelogenous Leukemia
venetoclax + chidamide
Sensitive: C3 – Early Trials
venetoclax + chidamide
Sensitive
:
C3
venetoclax + chidamide
Sensitive: C3 – Early Trials
venetoclax + chidamide
Sensitive
:
C3
IDH1 mutation + TP53 mutation
Acute Myelogenous Leukemia
IDH1 mutation + TP53 mutation
Acute Myelogenous Leukemia
venetoclax + chidamide
Sensitive: C3 – Early Trials
venetoclax + chidamide
Sensitive
:
C3
venetoclax + chidamide
Sensitive: C3 – Early Trials
venetoclax + chidamide
Sensitive
:
C3
TP53 mutation
Diffuse Large B Cell Lymphoma
TP53 mutation
Diffuse Large B Cell Lymphoma
chidamide
Sensitive: C4 – Case Studies
chidamide
Sensitive
:
C4
chidamide
Sensitive: C4 – Case Studies
chidamide
Sensitive
:
C4
ARID1A mutation
Lymphoma
ARID1A mutation
Lymphoma
chidamide
Sensitive: C4 – Case Studies
chidamide
Sensitive
:
C4
chidamide
Sensitive: C4 – Case Studies
chidamide
Sensitive
:
C4
MYC overexpression + BCL2 overexpression
Diffuse Large B Cell Lymphoma
MYC overexpression + BCL2 overexpression
Diffuse Large B Cell Lymphoma
doxorubicin hydrochloride + chidamide
Sensitive: D – Preclinical
doxorubicin hydrochloride + chidamide
Sensitive
:
D
doxorubicin hydrochloride + chidamide
Sensitive: D – Preclinical
doxorubicin hydrochloride + chidamide
Sensitive
:
D
HER-2 positive
HER2 Positive Breast Cancer
HER-2 positive
HER2 Positive Breast Cancer
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
MET overexpression
Non Small Cell Lung Cancer
MET overexpression
Non Small Cell Lung Cancer
crizotinib + chidamide
Sensitive: D – Preclinical
crizotinib + chidamide
Sensitive
:
D
crizotinib + chidamide
Sensitive: D – Preclinical
crizotinib + chidamide
Sensitive
:
D
FBXW7 mutation
Squamous Cell Carcinoma of Head and Neck
FBXW7 mutation
Squamous Cell Carcinoma of Head and Neck
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
ZBTB16-RARA fusion
Acute Promyelocytic Leukemia
ZBTB16-RARA fusion
Acute Promyelocytic Leukemia
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
STAT5b-RARA fusion
Acute Promyelocytic Leukemia
STAT5b-RARA fusion
Acute Promyelocytic Leukemia
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
NPM-RARA fusion
Acute Promyelocytic Leukemia
NPM-RARA fusion
Acute Promyelocytic Leukemia
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
KMT2D mutation
Chronic Lymphocytic Leukemia
KMT2D mutation
Chronic Lymphocytic Leukemia
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
KMT2D mutation
Chronic Lymphocytic Leukemia
KMT2D mutation
Chronic Lymphocytic Leukemia
ibrutinib + chidamide
Sensitive: D – Preclinical
ibrutinib + chidamide
Sensitive
:
D
ibrutinib + chidamide
Sensitive: D – Preclinical
ibrutinib + chidamide
Sensitive
:
D
EZH2 mutation
Diffuse Large B Cell Lymphoma
EZH2 mutation
Diffuse Large B Cell Lymphoma
chidamide + SHR-2554
Sensitive: D – Preclinical
chidamide + SHR-2554
Sensitive
:
D
chidamide + SHR-2554
Sensitive: D – Preclinical
chidamide + SHR-2554
Sensitive
:
D
PAX3-FOXO1 fusion
Rhabdomyosarcoma
PAX3-FOXO1 fusion
Rhabdomyosarcoma
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
CDH1 deletion
Breast Cancer
CDH1 deletion
Breast Cancer
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
CDH1 deletion
Gastric Cancer
CDH1 deletion
Gastric Cancer
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
entinostat
Sensitive: D – Preclinical
entinostat
Sensitive
:
D
TP53 wild-type
Breast Cancer
TP53 wild-type
Breast Cancer
selinexor + chidamide
Sensitive: D – Preclinical
selinexor + chidamide
Sensitive
:
D
selinexor + chidamide
Sensitive: D – Preclinical
selinexor + chidamide
Sensitive
:
D
TP53 wild-type
Breast Cancer
TP53 wild-type
Breast Cancer
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
chidamide
Sensitive: D – Preclinical
chidamide
Sensitive
:
D
TP53 wild-type + ER positive
HER2 Negative Breast Cancer
TP53 wild-type + ER positive
HER2 Negative Breast Cancer
selinexor + chidamide
Sensitive: D – Preclinical
selinexor + chidamide
Sensitive
:
D
selinexor + chidamide
Sensitive: D – Preclinical
selinexor + chidamide
Sensitive
:
D
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