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BIOMARKER:

HR positive + BRCA1 mutation + PALB2 mutation

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Entrez ID:

2099; 5241; 672; 79728

Related biomarkers:

‹

ER positive (199)

HR positive (184)

HR negative (25)

ER negative (13)

ER positive + PGR positive (12)

PGR positive (10)

HR positive + HER-2 negative (5)

ER expression (3)

ER overexpression (3)

IRF8 overexpression + ER negative (3)

BRCA1 expression (3)

ER positive + HER-2 negative (2)

ER positive + PGR negative (2)

FGFR1 overexpression + HR positive (2)

HR negative + PD-L1 expression (2)

HR positive + ER overexpression (2)

HR positive + HER-2 underexpression (2)

PGR expression (2)

PGR overexpression (2)

BRCA1 positive (2)

BRCA1 underexpression (2)

AR positive + ER positive (1)

CETN2 overexpression + HR positive (1)

CETN2 overexpression + MLH3 overexpression + PCNA overexpression + HR positive (1)

CTSD positive + ER positive (1)

ER negative + HER-2 negative (1)

ER positive + CDK6 overexpression (1)

ER positive + PGR negative + HER-2 negative (1)

ER underexpression (1)

HDC overexpression + HR positive (1)

HER-2 underexpression + ER underexpression (1)

HR overexpression (1)

HR positive + AR positive (1)

HR positive + BRCA positive (1)

HR positive + CCNE1 overexpression (1)

HR positive + ERBB3 overexpression (1)

HR positive + ERBB3 underexpression (1)

HR positive + HER-2 positive (1)

HR positive + PD-L1 expression (1)

HR positive + PLK1 overexpression (1)

HR positive + TNFRSF11A overexpression (1)

MLH3 overexpression + HR positive (1)

NOTCH3 expression + ER positive + PGR positive (1)

PCNA overexpression + HR positive (1)

PD-L1 overexpression + ER positive (1)

RAD51 overexpression + HR positive (1)

RFC3 overexpression + ER positive (1)

TFF1 overexpression + ER positive (1)

TFF3 overexpression + ER positive (1)

TNFRSF1A overexpression + HR positive (1)

TYMS overexpression + HR positive (1)

PGR negative (1)

BRCA1 negative (1)

BIN3 expression + ER positive (0)

CCNA2 expression + ER positive (0)

CCNB2 expression + ER positive (0)

CTDSP1 expression + ER positive (0)

EPRS1 expression + ER positive (0)

ER negative + HER-2 positive (0)

ER negative + PGR positive (0)

ER positive + HER-2 positive (0)

ER positive + PGR positive + HER-2 positive (0)

FOXD1 expression + ER positive (0)

FTO expression + ER positive (0)

HER-2 negative + AR positive + ER positive (0)

HER-2 negative + ER positive (0)

HR negative + HER-2 positive (0)

MIEN1 expression + ER negative + PR negative (0)

NCOR2 overexpression + ER positive (0)

RBPMS expression + ER positive (0)

SLBP expression + ER positive (0)

WSB2 expression + ER positive (0)

HER-2 negative + PGR positive (0)

PGR positive + HER-2 positive (0)

ER positive (199)

HR positive (184)

HR negative (25)

ER negative (13)

ER positive + PGR positive (12)

PGR positive (10)

HR positive + HER-2 negative (5)

ER expression (3)

ER overexpression (3)

IRF8 overexpression + ER negative (3)

BRCA1 expression (3)

ER positive + HER-2 negative (2)

ER positive + PGR negative (2)

FGFR1 overexpression + HR positive (2)

HR negative + PD-L1 expression (2)

HR positive + ER overexpression (2)

HR positive + HER-2 underexpression (2)

PGR expression (2)

PGR overexpression (2)

BRCA1 positive (2)

BRCA1 underexpression (2)

AR positive + ER positive (1)

CETN2 overexpression + HR positive (1)

CETN2 overexpression + MLH3 overexpression + PCNA overexpression + HR positive (1)

CTSD positive + ER positive (1)

ER negative + HER-2 negative (1)

ER positive + CDK6 overexpression (1)

ER positive + PGR negative + HER-2 negative (1)

ER underexpression (1)

HDC overexpression + HR positive (1)

HER-2 underexpression + ER underexpression (1)

HR overexpression (1)

HR positive + AR positive (1)

HR positive + BRCA positive (1)

HR positive + CCNE1 overexpression (1)

HR positive + ERBB3 overexpression (1)

HR positive + ERBB3 underexpression (1)

HR positive + HER-2 positive (1)

HR positive + PD-L1 expression (1)

HR positive + PLK1 overexpression (1)

HR positive + TNFRSF11A overexpression (1)

MLH3 overexpression + HR positive (1)

NOTCH3 expression + ER positive + PGR positive (1)

PCNA overexpression + HR positive (1)

PD-L1 overexpression + ER positive (1)

RAD51 overexpression + HR positive (1)

RFC3 overexpression + ER positive (1)

TFF1 overexpression + ER positive (1)

TFF3 overexpression + ER positive (1)

TNFRSF1A overexpression + HR positive (1)

TYMS overexpression + HR positive (1)

PGR negative (1)

BRCA1 negative (1)

BIN3 expression + ER positive (0)

CCNA2 expression + ER positive (0)

CCNB2 expression + ER positive (0)

CTDSP1 expression + ER positive (0)

EPRS1 expression + ER positive (0)

ER negative + HER-2 positive (0)

ER negative + PGR positive (0)

ER positive + HER-2 positive (0)

ER positive + PGR positive + HER-2 positive (0)

FOXD1 expression + ER positive (0)

FTO expression + ER positive (0)

HER-2 negative + AR positive + ER positive (0)

HER-2 negative + ER positive (0)

HR negative + HER-2 positive (0)

MIEN1 expression + ER negative + PR negative (0)

NCOR2 overexpression + ER positive (0)

RBPMS expression + ER positive (0)

SLBP expression + ER positive (0)

WSB2 expression + ER positive (0)

HER-2 negative + PGR positive (0)

PGR positive + HER-2 positive (0)

›

HR positive + BRCA1 mutation + PALB2 mutation

HER2 Negative Breast Cancer

CDK4 inhibitor + CDK6 inhibitor

Resistant: C3 – Early Trials

CDK4 inhibitor + CDK6 inhibitor

CDK4 inhibitor + CDK6 inhibitor

Resistant: C3 – Early Trials

CDK4 inhibitor + CDK6 inhibitor