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BIOMARKER:
HER-2 positive + PD-L1 expression
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule
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Entrez ID:
2064
;
29126
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
PD-L1 expression (356)
HER-2 positive (332)
PD-L1 overexpression (181)
HER-2 overexpression (132)
HER-2 negative (120)
HER-2 expression (87)
PD-L1 underexpression (46)
HER-2 underexpression (38)
PD-L1 negative (28)
HER-2 negative + PD-L1 expression (12)
HR positive + HER-2 negative (5)
CD47 positive + HER-2 positive (2)
CLDN18.2 expression + HER-2 negative (2)
CLDN18.2 positive + HER-2 negative (2)
EGFR overexpression + HER-2 overexpression (2)
ER positive + HER-2 negative (2)
FGFR2b overexpression + HER-2 negative (2)
HR positive + HER-2 underexpression (2)
PD-L1 expression + HER-2 overexpression (2)
HR negative + PD-L1 expression (2)
MSLN overexpression + PD-L1 overexpression (2)
PD-L1 expression + CD68 positive (2)
PD-L1 expression + PVR expression (2)
PD-L1 overexpression + CD8 overexpression (2)
TTF1 expression + PD-L1 expression (2)
miR-625-5p underexpression + PD-L1 overexpression (2)
CEACAM6 positive + HER-2 positive (1)
EGFR expression + HER-2 expression (1)
ER negative + HER-2 negative (1)
ER positive + PGR negative + HER-2 negative (1)
HER-2 positive + CAV1 overexpression (1)
HER-2 underexpression + ER underexpression (1)
HR positive + HER-2 positive (1)
MET expression + HER-2 expression (1)
MET overexpression + HER-2 overexpression (1)
TPBG underexpression + HER-2 overexpression (1)
TROP2 expression + HER-2 underexpression (1)
AXL overexpression + PD-L1 expression (1)
CGAS overexpression + PD-L1 overexpression (1)
CMTM4 expression + PD-L1 expression (1)
CMTM6 expression + PD-L1 expression (1)
CMTM6 overexpression + PD-L1 overexpression (1)
CXCL12 expression + PD-L1 underexpression (1)
HLA-A underexpression + PD-L1 expression (1)
HR positive + PD-L1 expression (1)
IGFBP2 overexpression + PD-L1 overexpression (1)
MHC-II overexpression + PD-L1 negative (1)
MHC-II overexpression + PD-L1 underexpression (1)
NKX2-1 expression + PD-L1 expression (1)
NR1H4 overexpression + PD‑L1 underexpression (1)
NT5E overexpression + PD-L1 expression (1)
PD-1 underexpression + PD-L1 overexpression (1)
PD-L1 expression + CD14 positive (1)
PD-L1 expression + CD47 expression (1)
PD-L1 expression + CD8 negative + GZMB negative (1)
PD-L1 expression + CD8 positive (1)
PD-L1 expression + CTLA4 expression (1)
PD-L1 expression + MTOR overexpression (1)
PD-L1 expression + REV3L overexpression (1)
PD-L1 overexpression + APOBEC3B overexpression (1)
PD-L1 overexpression + CCL5 overexpression (1)
PD-L1 overexpression + CD163 underexpression (1)
PD-L1 overexpression + ER positive (1)
PD-L1 overexpression + GZMA overexpression (1)
PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)
PD-L1 overexpression + PD-L2 underexpression (1)
PD-L1 overexpression + SOX2 overexpression (1)
RBM17 expression + PD-L1 expression (1)
RET positive + PD-L1 overexpression (1)
SNX20 overexpression + PD-L1 overexpression (1)
STK11 underexpression + PD-L1 overexpression (1)
TFRC overexpression + PD-L1 underexpression (1)
TNFSF4 overexpression + PD-L1 overexpression (1)
TTF1 expression + PD-L1 overexpression (1)
ER negative + HER-2 positive (0)
ER positive + HER-2 positive (0)
ER positive + PGR positive + HER-2 positive (0)
HER-2 amplification + HR-positive (0)
HER-2 negative + AR positive + ER positive (0)
HER-2 negative + CLDN18.2 positive (0)
HER-2 negative + ER positive (0)
HER-2 negative + FGFR2b overexpression (0)
HER-2 negative + HR negative (0)
HER-2 negative + HR negative + PD-L1 expression (0)
HER-2 negative + PGR positive (0)
HER-2 overexpression + HR negative (0)
HER-2 overexpression + HR positive (0)
HER-2 positive + HER-2 overexpression (0)
HER-2 positive + HR negative (0)
HER-2 positive + RAS wild-type (0)
HR negative + HER-2 positive (0)
PD-L1 expression + HER-2 expression (0)
PGR positive + HER-2 positive (0)
PD-L1 expression + LAG3 expression (0)
PD-L1 expression + TTF1 expression (0)
TMB + PD-L1 expression (0)
PD-L1 expression (356)
HER-2 positive (332)
PD-L1 overexpression (181)
HER-2 overexpression (132)
HER-2 negative (120)
HER-2 expression (87)
PD-L1 underexpression (46)
HER-2 underexpression (38)
PD-L1 negative (28)
HER-2 negative + PD-L1 expression (12)
HR positive + HER-2 negative (5)
CD47 positive + HER-2 positive (2)
CLDN18.2 expression + HER-2 negative (2)
CLDN18.2 positive + HER-2 negative (2)
EGFR overexpression + HER-2 overexpression (2)
ER positive + HER-2 negative (2)
FGFR2b overexpression + HER-2 negative (2)
HR positive + HER-2 underexpression (2)
PD-L1 expression + HER-2 overexpression (2)
HR negative + PD-L1 expression (2)
MSLN overexpression + PD-L1 overexpression (2)
PD-L1 expression + CD68 positive (2)
PD-L1 expression + PVR expression (2)
PD-L1 overexpression + CD8 overexpression (2)
TTF1 expression + PD-L1 expression (2)
miR-625-5p underexpression + PD-L1 overexpression (2)
CEACAM6 positive + HER-2 positive (1)
EGFR expression + HER-2 expression (1)
ER negative + HER-2 negative (1)
ER positive + PGR negative + HER-2 negative (1)
HER-2 positive + CAV1 overexpression (1)
HER-2 underexpression + ER underexpression (1)
HR positive + HER-2 positive (1)
MET expression + HER-2 expression (1)
MET overexpression + HER-2 overexpression (1)
TPBG underexpression + HER-2 overexpression (1)
TROP2 expression + HER-2 underexpression (1)
AXL overexpression + PD-L1 expression (1)
CGAS overexpression + PD-L1 overexpression (1)
CMTM4 expression + PD-L1 expression (1)
CMTM6 expression + PD-L1 expression (1)
CMTM6 overexpression + PD-L1 overexpression (1)
CXCL12 expression + PD-L1 underexpression (1)
HLA-A underexpression + PD-L1 expression (1)
HR positive + PD-L1 expression (1)
IGFBP2 overexpression + PD-L1 overexpression (1)
MHC-II overexpression + PD-L1 negative (1)
MHC-II overexpression + PD-L1 underexpression (1)
NKX2-1 expression + PD-L1 expression (1)
NR1H4 overexpression + PD‑L1 underexpression (1)
NT5E overexpression + PD-L1 expression (1)
PD-1 underexpression + PD-L1 overexpression (1)
PD-L1 expression + CD14 positive (1)
PD-L1 expression + CD47 expression (1)
PD-L1 expression + CD8 negative + GZMB negative (1)
PD-L1 expression + CD8 positive (1)
PD-L1 expression + CTLA4 expression (1)
PD-L1 expression + MTOR overexpression (1)
PD-L1 expression + REV3L overexpression (1)
PD-L1 overexpression + APOBEC3B overexpression (1)
PD-L1 overexpression + CCL5 overexpression (1)
PD-L1 overexpression + CD163 underexpression (1)
PD-L1 overexpression + ER positive (1)
PD-L1 overexpression + GZMA overexpression (1)
PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)
PD-L1 overexpression + PD-L2 underexpression (1)
PD-L1 overexpression + SOX2 overexpression (1)
RBM17 expression + PD-L1 expression (1)
RET positive + PD-L1 overexpression (1)
SNX20 overexpression + PD-L1 overexpression (1)
STK11 underexpression + PD-L1 overexpression (1)
TFRC overexpression + PD-L1 underexpression (1)
TNFSF4 overexpression + PD-L1 overexpression (1)
TTF1 expression + PD-L1 overexpression (1)
ER negative + HER-2 positive (0)
ER positive + HER-2 positive (0)
ER positive + PGR positive + HER-2 positive (0)
HER-2 amplification + HR-positive (0)
HER-2 negative + AR positive + ER positive (0)
HER-2 negative + CLDN18.2 positive (0)
HER-2 negative + ER positive (0)
HER-2 negative + FGFR2b overexpression (0)
HER-2 negative + HR negative (0)
HER-2 negative + HR negative + PD-L1 expression (0)
HER-2 negative + PGR positive (0)
HER-2 overexpression + HR negative (0)
HER-2 overexpression + HR positive (0)
HER-2 positive + HER-2 overexpression (0)
HER-2 positive + HR negative (0)
HER-2 positive + RAS wild-type (0)
HR negative + HER-2 positive (0)
PD-L1 expression + HER-2 expression (0)
PGR positive + HER-2 positive (0)
PD-L1 expression + LAG3 expression (0)
PD-L1 expression + TTF1 expression (0)
TMB + PD-L1 expression (0)
›
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
HER-2 positive + PD-L1 expression
Gastroesophageal Junction Adenocarcinoma
HER-2 positive + PD-L1 expression
Gastroesophageal Junction Adenocarcinoma
pembrolizumab + trastuzumab
Sensitive: A1 - Approval
pembrolizumab + trastuzumab
Sensitive
:
A1
pembrolizumab + trastuzumab
Sensitive: A1 - Approval
pembrolizumab + trastuzumab
Sensitive
:
A1
HER-2 positive + PD-L1 expression
Gastric Cancer
HER-2 positive + PD-L1 expression
Gastric Cancer
pembrolizumab + trastuzumab
Sensitive: A1 - Approval
pembrolizumab + trastuzumab
Sensitive
:
A1
pembrolizumab + trastuzumab
Sensitive: A1 - Approval
pembrolizumab + trastuzumab
Sensitive
:
A1
HER-2 positive + PD-L1 expression
Gastroesophageal Cancer
HER-2 positive + PD-L1 expression
Gastroesophageal Cancer
margetuximab-cmkb + retifanlimab-dlwr
Sensitive: C3 – Early Trials
margetuximab-cmkb + retifanlimab-dlwr
Sensitive
:
C3
margetuximab-cmkb + retifanlimab-dlwr
Sensitive: C3 – Early Trials
margetuximab-cmkb + retifanlimab-dlwr
Sensitive
:
C3
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