BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells....Most cell lines showed reduced viability with increasing doses of JQ1 (Figure ​(Figure2A).2A). However, the cells with Gnaq/11 mutations were the most sensitive to the treatments with IC50 of 100–250 nM, suggesting a dependency on functional BET proteins.