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GENE:

GDF15 (Growth differentiation factor 15)

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GDF15 overexpression	Oral Cancer	GDF15 overexpression	Oral Cancer	Sensitive: C3 – Early Trials Sensitive : C3	Sensitive: C3 – Early Trials Sensitive : C3
GDF15 elevation	Melanoma	GDF15 elevation	Melanoma	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3
GDF15 elevation	Melanoma	GDF15 elevation	Melanoma	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3
GDF15-L	Melanoma	GDF15-L	Melanoma	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
GDF15-L	Non Small Cell Lung Cancer	GDF15-L	Non Small Cell Lung Cancer	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
GDF15-L	Non Small Cell Lung Cancer	GDF15-L	Non Small Cell Lung Cancer	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3
GDF15 overexpression	Oral Cancer	GDF15 overexpression	Oral Cancer	CI-1033 Sensitive: D – Preclinical CI-1033 Sensitive : D	CI-1033 Sensitive: D – Preclinical CI-1033 Sensitive : D