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DRUG CLASS:

Folate analog

DRUG CLASS:

Folate analog

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leucovorin calcium (13)

levoleucovorin (0)

levoleucovorin calcium (0)

leucovorin calcium (13)

levoleucovorin (0)

levoleucovorin calcium (0)

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No biomarker	Pancreatic Adenocarcinoma	No biomarker	Pancreatic Adenocarcinoma	5-fluorouracil + leucovorin calcium + nanoliposomal irinotecan Sensitive: A1 - Approval 5-fluorouracil + leucovorin calcium + nanoliposomal irinotecan Sensitive : A1	5-fluorouracil + leucovorin calcium + nanoliposomal irinotecan Sensitive: A1 - Approval 5-fluorouracil + leucovorin calcium + nanoliposomal irinotecan Sensitive : A1
No biomarker	Ovarian Cancer	No biomarker	Ovarian Cancer	leucovorin calcium Sensitive: A2 - Guideline leucovorin calcium Sensitive : A2	leucovorin calcium Sensitive: A2 - Guideline leucovorin calcium Sensitive : A2
No biomarker	Colon Cancer	No biomarker	Colon Cancer	5-fluorouracil + oxaliplatin + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + oxaliplatin + leucovorin calcium Sensitive : A2	5-fluorouracil + oxaliplatin + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + oxaliplatin + leucovorin calcium Sensitive : A2
No biomarker	Colorectal Cancer	No biomarker	Colorectal Cancer	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2
No biomarker	Colorectal Cancer	No biomarker	Colorectal Cancer	leucovorin calcium Sensitive: A2 - Guideline leucovorin calcium Sensitive : A2	leucovorin calcium Sensitive: A2 - Guideline leucovorin calcium Sensitive : A2
No biomarker	Rectal Cancer	No biomarker	Rectal Cancer	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2
No biomarker	Biliary Tract Cancer	No biomarker	Biliary Tract Cancer	5-fluorouracil + irinotecan + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + irinotecan + leucovorin calcium Sensitive : A2	5-fluorouracil + irinotecan + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + irinotecan + leucovorin calcium Sensitive : A2
No biomarker	Colon Cancer	No biomarker	Colon Cancer	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2
No biomarker	Pancreatic Adenocarcinoma	No biomarker	Pancreatic Adenocarcinoma	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2
No biomarker	Pancreatic Adenocarcinoma	No biomarker	Pancreatic Adenocarcinoma	gemcitabine + 5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline gemcitabine + 5-fluorouracil + leucovorin calcium Sensitive : A2	gemcitabine + 5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline gemcitabine + 5-fluorouracil + leucovorin calcium Sensitive : A2
No biomarker	Ampulla of Vater Carcinoma	No biomarker	Ampulla of Vater Carcinoma	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2	5-fluorouracil + leucovorin calcium Sensitive: A2 - Guideline 5-fluorouracil + leucovorin calcium Sensitive : A2
ABCC3 overexpression	Colorectal Cancer	ABCC3 overexpression	Colorectal Cancer	5-fluorouracil + leucovorin calcium Sensitive: C3 – Early Trials 5-fluorouracil + leucovorin calcium Sensitive : C3	5-fluorouracil + leucovorin calcium Sensitive: C3 – Early Trials 5-fluorouracil + leucovorin calcium Sensitive : C3
GATA6 underexpression	Pancreatic Ductal Adenocarcinoma	GATA6 underexpression	Pancreatic Ductal Adenocarcinoma	leucovorin calcium Resistant: C3 – Early Trials leucovorin calcium Resistant : C3	leucovorin calcium Resistant: C3 – Early Trials leucovorin calcium Resistant : C3