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Association details:
| Biomarker: | ABCC3 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) + leucovorin calcium (Folate analog) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Folate gene prediction of treatment response to 5-FU and leucovorin in advanced colorectal cancer.
Published date:
05/16/2018
Excerpt:
High expression of ABCC3 may therefore cause a high conversion rate of LV to co-factor, and enhanced inhibition of TYMS...ABCC3 expression levels were divided into tertiles; the low, intermediate and high levels...The high expression group had a median PFS of 10.1 months compared to 6.5 months among patients in the low expression group... Folate-related genes predict response to treatment with FLV in stage III and IV CRC.
DOI:
10.1200/JCO.2018.36.15_suppl.3550
