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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Antileukemic Activity of Lintuzumab‑Ac225 in Preclinical Model of FLT3 Mutant AML

Published date:
09/01/2023
Excerpt:
In this study, we evaluated the antileukemic activity of lintuzumab-Ac225 in FLT3 mutant AML as a single agent and in combination with the FLT3-targeted inhibitor gilteritinib….Treatment of MV-4-11 cells with lintuzumab-Ac225 resulted in a dose-dependent reduction of cell viability within 48 hours which was significantly more potent relative to non-labeled lintuzumab or gilteritinib alone. The combination of lintuzumab-Ac225 with gilteritinib further reduced cell viability relative to relative to single agents at the dose levels studied…. Our findings show that single-agent lintuzumab-Ac225 has potent antileukemic activity against FLT3 mutant AML and can significantly improve the effect of FLT3 inhibitors in combination.