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Association details:
| Biomarker: | FLT3-ITD mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | CDDD11-8 (FLT3 inhibitor, CDK9 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An Orally Bioavailable and Highly Efficacious Inhibitor of CDK9/FLT3 for the Treatment of Acute Myeloid Leukemia
Published date:
02/22/2022
Excerpt:
CDDD11-8 displayed antiproliferative activity against leukemia cell lines, and particularly potent effects were observed against MV4-11 and MOLM-13 cells, which are known to harbor the FLT3-ITD mutation and mixed lineage leukemia (MLL) fusion proteins...DDD11-8 induced tumor regression, and this was translated to an improved survival of animals.
DOI:
10.3390/cancers14051113
