^
Association details:
| Biomarker: | FLT3 D835Y |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Max-40279 (PDGFR inhibitor, FLT3 inhibitor, FGFR1 inhibitor, FGFR2 inhibitor, JAK inhibitor, HPK1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Evaluation of MAX-40279, a FLT3/FGFR Dual Kinase Inhibitor for Treatment of Acute Myeloid Leukemia
Published date:
11/01/2018
Excerpt:
At the enzyme level, FLT3-wt, FLT3-ITD and FLT3-D835Y were compared….In addition, MAX-40279 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the urrent FLT3 inhibitors...
DOI:
https://doi.org/10.1182/blood-2018-99-110414
