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BIOMARKER:
FGFR2 amplification
i
Other names:
FGFR2, BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, Fibroblast growth factor receptor 2
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Entrez ID:
2263
Related biomarkers:
Expression
Mutation
Fusion
Others
‹
FGFR2 mutation (30)
FGFR2 N549K (7)
FGFR2 rearrangement (7)
FGFR2 P253R (3)
FGFR2 K310R (2)
FGFR2 translocation (2)
ARID1A K1238fs + FGFR2 R210Q (1)
BAP1 mutation + FGFR2 rearrangement (1)
FDFT1 rearrangement + FGFR2 rearrangement (1)
FGFR2 A391E (1)
FGFR2 B252W (1)
FGFR2 C382R (1)
FGFR2 E250G (1)
FGFR2 E565A (1)
FGFR2 E565G (1)
FGFR2 E565K (1)
FGFR2 F276C (1)
FGFR2 M540_I541insMM (1)
FGFR2 N549D (1)
FGFR2 N549H (1)
FGFR2 N549T (1)
FGFR2 N550K (1)
FGFR2 S252W (1)
FGFR2 V564F (1)
FGFR2 V564I (1)
FGFR2 V564L (1)
FGFR2 Y375C (1)
FGFR2 Y376C (1)
PIK3CA mutation + FGFR2 rearrangement (1)
PIK3CB mutation + FGFR2 rearrangement (1)
PIK3R1 mutation + FGFR2 rearrangement (1)
TP53 mutation + FGFR2 rearrangement (1)
FGFR2 C383R (0)
FGFR2 K660N (0)
FGFR2 W290C (0)
FGFR2 wild-type (0)
FGFR2 mutation (30)
FGFR2 N549K (7)
FGFR2 rearrangement (7)
FGFR2 P253R (3)
FGFR2 K310R (2)
FGFR2 translocation (2)
ARID1A K1238fs + FGFR2 R210Q (1)
BAP1 mutation + FGFR2 rearrangement (1)
FDFT1 rearrangement + FGFR2 rearrangement (1)
FGFR2 A391E (1)
FGFR2 B252W (1)
FGFR2 C382R (1)
FGFR2 E250G (1)
FGFR2 E565A (1)
FGFR2 E565G (1)
FGFR2 E565K (1)
FGFR2 F276C (1)
FGFR2 M540_I541insMM (1)
FGFR2 N549D (1)
FGFR2 N549H (1)
FGFR2 N549T (1)
FGFR2 N550K (1)
FGFR2 S252W (1)
FGFR2 V564F (1)
FGFR2 V564I (1)
FGFR2 V564L (1)
FGFR2 Y375C (1)
FGFR2 Y376C (1)
PIK3CA mutation + FGFR2 rearrangement (1)
PIK3CB mutation + FGFR2 rearrangement (1)
PIK3R1 mutation + FGFR2 rearrangement (1)
TP53 mutation + FGFR2 rearrangement (1)
FGFR2 C383R (0)
FGFR2 K660N (0)
FGFR2 W290C (0)
FGFR2 wild-type (0)
›
Associations
News
Trials
VERI cancer hierarchy
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FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 amplification
Cholangiocarcinoma
FGFR2 amplification
Cholangiocarcinoma
ARQ 087
Sensitive: C2 – Inclusion Criteria
ARQ 087
Sensitive
:
C2
ARQ 087
Sensitive: C2 – Inclusion Criteria
ARQ 087
Sensitive
:
C2
FGFR2 amplification
Gastroesophageal Cancer
FGFR2 amplification
Gastroesophageal Cancer
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
AMG 552
Sensitive: C2 – Inclusion Criteria
AMG 552
Sensitive
:
C2
AMG 552
Sensitive: C2 – Inclusion Criteria
AMG 552
Sensitive
:
C2
FGFR2 amplification
Gastroesophageal Junction Adenocarcinoma
FGFR2 amplification
Gastroesophageal Junction Adenocarcinoma
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 amplification
Triple Negative Breast Cancer
FGFR2 amplification
Triple Negative Breast Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
Debio 1347
Resistant: C3 – Early Trials
Debio 1347
Resistant
:
C3
Debio 1347
Resistant: C3 – Early Trials
Debio 1347
Resistant
:
C3
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
Debio 1347
Sensitive: C3 – Early Trials
Debio 1347
Sensitive
:
C3
Debio 1347
Sensitive: C3 – Early Trials
Debio 1347
Sensitive
:
C3
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
FGFR inhibitor
Sensitive: C3 – Early Trials
FGFR inhibitor
Sensitive
:
C3
FGFR inhibitor
Sensitive: C3 – Early Trials
FGFR inhibitor
Sensitive
:
C3
FGFR2 amplification
Hormone Receptor Positive Breast Cancer
FGFR2 amplification
Hormone Receptor Positive Breast Cancer
palbociclib + BAY 1163877
Sensitive: C3 – Early Trials
palbociclib + BAY 1163877
Sensitive
:
C3
palbociclib + BAY 1163877
Sensitive: C3 – Early Trials
palbociclib + BAY 1163877
Sensitive
:
C3
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR2 amplification
Gastric Adenocarcinoma
FGFR2 amplification
Gastric Adenocarcinoma
futibatinib
Sensitive: D – Preclinical
futibatinib
Sensitive
:
D
futibatinib
Sensitive: D – Preclinical
futibatinib
Sensitive
:
D
FGFR2 amplification
Colorectal Cancer
FGFR2 amplification
Colorectal Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
erdafitinib
Sensitive: D – Preclinical
erdafitinib
Sensitive
:
D
erdafitinib
Sensitive: D – Preclinical
erdafitinib
Sensitive
:
D
FGFR2 amplification
Colorectal Cancer
FGFR2 amplification
Colorectal Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR2 amplification
Non Small Cell Lung Cancer
FGFR2 amplification
Non Small Cell Lung Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 amplification
Gastric Adenocarcinoma
FGFR2 amplification
Gastric Adenocarcinoma
nintedanib
Sensitive: D – Preclinical
nintedanib
Sensitive
:
D
nintedanib
Sensitive: D – Preclinical
nintedanib
Sensitive
:
D
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