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BIOMARKER:
FGFR2 amplification
i
Other names:
FGFR2, BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, Fibroblast growth factor receptor 2
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Entrez ID:
2263
Related biomarkers:
Expression
Mutation
Fusion
Others
‹
FGFR2 overexpression (8)
FGFR2 expression (3)
FGFR2b expression (3)
FGFR2b overexpression (2)
FGFR2b overexpression + HER-2 negative (2)
FGFR2b positive (2)
FGFR2 underexpression (1)
FGFR2 underexpression + FGFR3 overexpression (1)
FGFR2 underexpression + FGFR3 expression (0)
HER-2 negative + FGFR2b overexpression (0)
FGFR2 overexpression (8)
FGFR2 expression (3)
FGFR2b expression (3)
FGFR2b overexpression (2)
FGFR2b overexpression + HER-2 negative (2)
FGFR2b positive (2)
FGFR2 underexpression (1)
FGFR2 underexpression + FGFR3 overexpression (1)
FGFR2 underexpression + FGFR3 expression (0)
HER-2 negative + FGFR2b overexpression (0)
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VERI cancer hierarchy
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FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 amplification
Cholangiocarcinoma
FGFR2 amplification
Cholangiocarcinoma
ARQ 087
Sensitive: C2 – Inclusion Criteria
ARQ 087
Sensitive
:
C2
ARQ 087
Sensitive: C2 – Inclusion Criteria
ARQ 087
Sensitive
:
C2
FGFR2 amplification
Gastroesophageal Cancer
FGFR2 amplification
Gastroesophageal Cancer
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
AMG 552
Sensitive: C2 – Inclusion Criteria
AMG 552
Sensitive
:
C2
AMG 552
Sensitive: C2 – Inclusion Criteria
AMG 552
Sensitive
:
C2
FGFR2 amplification
Gastroesophageal Junction Adenocarcinoma
FGFR2 amplification
Gastroesophageal Junction Adenocarcinoma
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR2 amplification
Triple Negative Breast Cancer
FGFR2 amplification
Triple Negative Breast Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
Debio 1347
Resistant: C3 – Early Trials
Debio 1347
Resistant
:
C3
Debio 1347
Resistant: C3 – Early Trials
Debio 1347
Resistant
:
C3
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
Debio 1347
Sensitive: C3 – Early Trials
Debio 1347
Sensitive
:
C3
Debio 1347
Sensitive: C3 – Early Trials
Debio 1347
Sensitive
:
C3
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
FGFR inhibitor
Sensitive: C3 – Early Trials
FGFR inhibitor
Sensitive
:
C3
FGFR inhibitor
Sensitive: C3 – Early Trials
FGFR inhibitor
Sensitive
:
C3
FGFR2 amplification
Hormone Receptor Positive Breast Cancer
FGFR2 amplification
Hormone Receptor Positive Breast Cancer
palbociclib + BAY 1163877
Sensitive: C3 – Early Trials
palbociclib + BAY 1163877
Sensitive
:
C3
palbociclib + BAY 1163877
Sensitive: C3 – Early Trials
palbociclib + BAY 1163877
Sensitive
:
C3
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR2 amplification
Gastric Adenocarcinoma
FGFR2 amplification
Gastric Adenocarcinoma
futibatinib
Sensitive: D – Preclinical
futibatinib
Sensitive
:
D
futibatinib
Sensitive: D – Preclinical
futibatinib
Sensitive
:
D
FGFR2 amplification
Colorectal Cancer
FGFR2 amplification
Colorectal Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
erdafitinib
Sensitive: D – Preclinical
erdafitinib
Sensitive
:
D
erdafitinib
Sensitive: D – Preclinical
erdafitinib
Sensitive
:
D
FGFR2 amplification
Colorectal Cancer
FGFR2 amplification
Colorectal Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR2 amplification
Non Small Cell Lung Cancer
FGFR2 amplification
Non Small Cell Lung Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 amplification
Gastric Cancer
FGFR2 amplification
Gastric Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR2 amplification
Breast Cancer
FGFR2 amplification
Breast Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR2 amplification
Gastric Adenocarcinoma
FGFR2 amplification
Gastric Adenocarcinoma
nintedanib
Sensitive: D – Preclinical
nintedanib
Sensitive
:
D
nintedanib
Sensitive: D – Preclinical
nintedanib
Sensitive
:
D
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