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Association details:
| Biomarker: | FGFR1 amplification |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | afimoxifene (Selective estrogen receptor modulator) |
| Direction: | Resistant |
Evidence:
Source:
Title:
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
Excerpt:
FGFR1-amplified breast cancer cell lines show resistance to 4-hydroxytamoxifen, which is reversed by small interfering RNA silencing of FGFR1.
DOI:
10.1158/0008-5472.CAN-09-3746
