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Association details:
| Biomarker: | FBXW7 underexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | JQ-1 (BET inhibitor) + S63845 (MCL1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Mcl-1 inhibition overcomes BET inhibitor resistance induced by low FBW7 expression in breast cancer
Published date:
02/07/2022
Excerpt:
In the current study, our data indicated that the low expression of FBW7 contributes to the drug resistance of BC cells upon JQ1 treatment....The combination of JQ1 with a Mcl-1 inhibitor (S63845) resensitized the FBW7 knockdown tumours to JQ1 treatment in vivo. Our study paves the way for a novel therapeutic potential of BETis with Mcl-1 inhibitors for BC patients with a low FBW7 expression.
DOI:
10.1111/jcmm.17210
