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BIOMARKER:
ETV6-NTRK3 fusion
i
Other names:
NTRK3, TRKC, Neurotrophic tyrosine kinase, receptor, type 3, ETV6, ETS Variant Transcription Factor 6, ETS Variant 6, Ets Variant Gene 6 (TEL Oncogene), ETS Translocation Variant 6, Transcription Factor ETV6, ETS-Related Protein Tel1, TEL, TEL1 Oncogene, TEL Oncogene, TEL/ABL, THC5, TEL1, Tel
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Entrez ID:
4916
;
2120
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
NTRK3 fusion (91)
EML4-NTRK3 fusion (2)
ETV6-NTRK3 G623R (1)
ETV6-NTRK3 fusion + CRTC3-NTRK3 fusion (1)
TPM4-NTRK3 fusion (1)
ETV6-ABL1 fusion (1)
ETV6-FGFR3 fusion (1)
ETV6-FLT3 fusion (1)
ETV6-NTRK2 fusion (1)
ETV6-PDGFRB fusion (1)
NTRK3 fusion (91)
EML4-NTRK3 fusion (2)
ETV6-NTRK3 G623R (1)
ETV6-NTRK3 fusion + CRTC3-NTRK3 fusion (1)
TPM4-NTRK3 fusion (1)
ETV6-ABL1 fusion (1)
ETV6-FGFR3 fusion (1)
ETV6-FLT3 fusion (1)
ETV6-NTRK2 fusion (1)
ETV6-PDGFRB fusion (1)
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Trials
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ETV6-NTRK3 fusion
Acute Lymphocytic Leukemia
ETV6-NTRK3 fusion
Acute Lymphocytic Leukemia
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
ETV6-NTRK3 fusion
Head and Neck Cancer
ETV6-NTRK3 fusion
Head and Neck Cancer
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
ETV6-NTRK3 fusion
Solid Tumor
ETV6-NTRK3 fusion
Solid Tumor
entrectinib
Sensitive: C3 – Early Trials
entrectinib
Sensitive
:
C3
entrectinib
Sensitive: C3 – Early Trials
entrectinib
Sensitive
:
C3
ETV6-NTRK3 fusion
Salivary Gland Cancer
ETV6-NTRK3 fusion
Salivary Gland Cancer
entrectinib
Resistant: C3 – Early Trials
entrectinib
Resistant
:
C3
entrectinib
Resistant: C3 – Early Trials
entrectinib
Resistant
:
C3
ETV6-NTRK3 fusion
Acute Myelogenous Leukemia
ETV6-NTRK3 fusion
Acute Myelogenous Leukemia
entrectinib
Sensitive: C3 – Early Trials
entrectinib
Sensitive
:
C3
entrectinib
Sensitive: C3 – Early Trials
entrectinib
Sensitive
:
C3
ETV6-NTRK3 fusion
Salivary Gland Cancer
ETV6-NTRK3 fusion
Salivary Gland Cancer
larotrectinib
Sensitive: C3 – Early Trials
larotrectinib
Sensitive
:
C3
larotrectinib
Sensitive: C3 – Early Trials
larotrectinib
Sensitive
:
C3
ETV6-NTRK3 fusion
Fibrosarcoma
ETV6-NTRK3 fusion
Fibrosarcoma
Resistant: C4 – Case Studies
Resistant
:
C4
Resistant: C4 – Case Studies
Resistant
:
C4
ETV6-NTRK3 fusion
Fibrosarcoma
ETV6-NTRK3 fusion
Fibrosarcoma
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
ETV6-NTRK3 fusion
Fibrosarcoma
ETV6-NTRK3 fusion
Fibrosarcoma
vincristine + dactinomycin
Resistant: C4 – Case Studies
vincristine + dactinomycin
Resistant
:
C4
vincristine + dactinomycin
Resistant: C4 – Case Studies
vincristine + dactinomycin
Resistant
:
C4
ETV6-NTRK3 fusion
Breast Cancer
ETV6-NTRK3 fusion
Breast Cancer
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
ETV6-NTRK3 fusion
Neuroendocrine Tumor
ETV6-NTRK3 fusion
Neuroendocrine Tumor
entrectinib
Sensitive: C4 – Case Studies
entrectinib
Sensitive
:
C4
entrectinib
Sensitive: C4 – Case Studies
entrectinib
Sensitive
:
C4
ETV6-NTRK3 fusion
Glioma
ETV6-NTRK3 fusion
Glioma
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
ETV6-NTRK3 fusion
Soft Tissue Sarcoma
ETV6-NTRK3 fusion
Soft Tissue Sarcoma
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
ETV6-NTRK3 fusion
Triple Negative Breast Cancer
ETV6-NTRK3 fusion
Triple Negative Breast Cancer
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
ETV6-NTRK3 fusion
Neuroblastoma
ETV6-NTRK3 fusion
Neuroblastoma
repotrectinib
Sensitive: D – Preclinical
repotrectinib
Sensitive
:
D
repotrectinib
Sensitive: D – Preclinical
repotrectinib
Sensitive
:
D
ETV6-NTRK3 fusion
Acute Lymphocytic Leukemia
ETV6-NTRK3 fusion
Acute Lymphocytic Leukemia
larotrectinib
Sensitive: D – Preclinical
larotrectinib
Sensitive
:
D
larotrectinib
Sensitive: D – Preclinical
larotrectinib
Sensitive
:
D
ETV6-NTRK3 fusion
Acute Lymphocytic Leukemia
ETV6-NTRK3 fusion
Acute Lymphocytic Leukemia
OPN-7486
Sensitive: D – Preclinical
OPN-7486
Sensitive
:
D
OPN-7486
Sensitive: D – Preclinical
OPN-7486
Sensitive
:
D
ETV6-NTRK3 fusion
Squamous Cell Carcinoma of Head and Neck
ETV6-NTRK3 fusion
Squamous Cell Carcinoma of Head and Neck
LY2801653
Sensitive: D – Preclinical
LY2801653
Sensitive
:
D
LY2801653
Sensitive: D – Preclinical
LY2801653
Sensitive
:
D
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