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BIOMARKER:

ETV6-NTRK3 fusion

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Other names: NTRK3, TRKC, Neurotrophic tyrosine kinase, receptor, type 3, ETV6, ETS Variant Transcription Factor 6, ETS Variant 6, Ets Variant Gene 6 (TEL Oncogene), ETS Translocation Variant 6, Transcription Factor ETV6, ETS-Related Protein Tel1, TEL, TEL1 Oncogene, TEL Oncogene, TEL/ABL, THC5, TEL1, Tel
Entrez ID:
ETV6-NTRK3 fusion
Soft Tissue Sarcoma
larotrectinib
Sensitive: C4 – Case Studies
J Pediatr Hematol Oncol - 3 weeks
ETV6-NTRK3 fusion
ALL
crizotinib
Sensitive: C3 – Early Trials
ETV6-NTRK3 fusion
Head and Neck Cancer
crizotinib
Sensitive: C3 – Early Trials
ETV6-NTRK3 fusion
Solid Tumor
entrectinib
Sensitive: C3 – Early Trials
ETV6-NTRK3 fusion
AML
entrectinib
Sensitive: C3 – Early Trials
ETV6-NTRK3 fusion
Salivary Gland Cancer
larotrectinib
Sensitive: C3 – Early Trials
ETV6-NTRK3 fusion
Fibrosarcoma
VAC
Resistant: C4 – Case Studies
ETV6-NTRK3 fusion
Fibrosarcoma
larotrectinib
Sensitive: C4 – Case Studies
ETV6-NTRK3 fusion
Fibrosarcoma
vincristine + dactinomycin
Resistant: C4 – Case Studies
ETV6-NTRK3 fusion
Salivary Gland Cancer
entrectinib
Resistant: C4 – Case Studies
ETV6-NTRK3 fusion
Breast Cancer
larotrectinib
Sensitive: C4 – Case Studies
ETV6-NTRK3 fusion
Neuroendocrine Tumor
entrectinib
Sensitive: C4 – Case Studies
ETV6-NTRK3 fusion
Glioma
larotrectinib
Sensitive: C4 – Case Studies
ETV6-NTRK3 fusion
Neuroblastoma
TPX-0005
Sensitive: D – Preclinical
ETV6-NTRK3 fusion
ALL
larotrectinib
Sensitive: D – Preclinical
ETV6-NTRK3 fusion
ALL
PLX7486
Sensitive: D – Preclinical
ETV6-NTRK3 fusion
SCCHN
LY2801653
Sensitive: D – Preclinical