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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | sotrastaurin (AEB071) (PKC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects
Published date:
03/17/2022
Excerpt:
Here were evaluated the AEB071 (Sotrastaurin™) treatment efficiency of breast cancer cell lines derived from estrogen receptor positive (T-47D), estrogen/HER2 receptor positive (BT474)... All breast cancer cell lines subjected to this study were sensitive to AEB071 treatment... A combined targeting of PKC and a subtype specific driver molecule might complement specified breast cancer treatment.
DOI:
10.1007/s00404-022-06434-2
