^
Association details:
| Biomarker: | EGFRVIII expression + PTEN expression |
|---|---|
| Cancer: | Glioma |
| Drug: | erlotinib (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors
Excerpt:
A clinical response in this group was also significantly associated with the coexpression of EGFRvIII and PTEN (odds ratio, 40; 95 percent confidence interval, 3 to 468; P=0.001).
DOI:
10.1056/NEJMoa051918
